Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
about
The generation and function of soluble apoE receptors in the CNSQuantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's diseaseSorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionMild cognitive impairment: pathology and mechanisms.Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's diseaseThe retromer complex - endosomal protein recycling and beyondThe genetics and neuropathology of Alzheimer's diseaseThe structure of MESD45-184 brings light into the mechanism of LDLR family foldingRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseSORL1 Gene is Associated with the Conversion from Mild Cognitive Impairment to Alzheimer's DiseaseHead Injury as a Risk Factor for Dementia and Alzheimer's Disease: A Systematic Review and Meta-Analysis of 32 Observational StudiesInteraction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's diseaseMint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics.Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Multi-compartmental modeling of SORLA's influence on amyloidogenic processing in Alzheimer's diseaseNeuronal LR11 expression does not differentiate between clinically-defined Alzheimer's disease and control brainsA membrane proximal helix in the cytosolic domain of the human APP interacting protein LR11/SorLA deforms liposomes.The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft traffickingBacterial expression, purification, and model membrane reconstitution of the transmembrane and cytoplasmic domains of the human APP binding protein LR11/SorLA for NMR studies.Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons.Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons.Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.An exploratory study of the association between SORL1 polymorphisms and sporadic Alzheimer's disease in the Han Chinese population.Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.Identification of Alzheimer disease-associated variants in genes that regulate retromer functionThe amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism.LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease.Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan.Computational method for calculating fluorescence intensities within three-dimensional structures in cellsAllelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues.Substrate specificity of gamma-secretase and other intramembrane proteases.Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease.
P2860
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P2860
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Molecular dissection of the in ...... afficking receptor SorLA/LR11.
@en
Molecular dissection of the in ...... afficking receptor SorLA/LR11.
@nl
type
label
Molecular dissection of the in ...... afficking receptor SorLA/LR11.
@en
Molecular dissection of the in ...... afficking receptor SorLA/LR11.
@nl
prefLabel
Molecular dissection of the in ...... afficking receptor SorLA/LR11.
@en
Molecular dissection of the in ...... afficking receptor SorLA/LR11.
@nl
P2093
P50
P356
P1433
P1476
Molecular dissection of the in ...... afficking receptor SorLA/LR11.
@en
P2093
Denise Galatis
Joachim Behlke
Jørgen Gliemann
Robert Spoelgen
Vanessa Schmidt
P304
P356
10.1021/BI052120V
P407
P50
P577
2006-02-01T00:00:00Z