Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia. - Wikidata - wikimedia - TriplyDB

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

http://www.wikidata.org/entity/Q48939108

about

Modeling Alzheimer's Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia TREM2 in CNS homeostasis and neurodegenerative disease Therapeutic and diagnostic challenges for frontotemporal dementia R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities Additional mechanisms conferring genetic susceptibility to Alzheimer's disease Next generation sequencing techniques in neurological diseases: redefining clinical and molecular associations.Coding variants in TREM2 increase risk for Alzheimer's disease Identification of rare variants in Alzheimer's disease.Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.TREM2 is associated with increased risk for Alzheimer's disease in African Americans.TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis.The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers.TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease.Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease.Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.Alzheimer's disease genetics: from the bench to the clinic.The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders.The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease.TREM2 in Neurodegenerative Diseases.The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases TREM2-Ligand Interactions in Health and Disease.A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.Novel susceptibility loci for Alzheimer's disease.The clinical spectrum of sporadic and familial forms of frontotemporal dementia.From Common to Rare Variants: The Genetic Component of Alzheimer Disease.

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Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

http://www.wikidata.org/entity/Q48939108

description

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年學術文章

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2013年學術文章

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name

Investigating the role of rare ...... e and frontotemporal dementia.

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Investigating the role of rare ...... e and frontotemporal dementia.

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Investigating the role of rare ...... e and frontotemporal dementia.

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Investigating the role of rare ...... e and frontotemporal dementia.

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Investigating the role of rare ...... e and frontotemporal dementia.

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Investigating the role of rare ...... e and frontotemporal dementia.

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J.NEUROBIOLAGING.2013.09.009

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Neurobiology of Aging

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Investigating the role of rare ...... e and frontotemporal dementia.

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BELNEU consortium

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Githa Maes

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Ilse Gijselinck

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10.1016/J.NEUROBIOLAGING.2013.09.009

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Christine Van Broeckhoven

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2013-10-09T00:00:00Z

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Alzheimer's disease