HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 - Wikidata - wikimedia - TriplyDB

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

http://www.wikidata.org/entity/Q50299999

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RAB GEFs exchange GTP for GDP on RABs

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Q45318469-FAEAA56A-4032-4793-A443-66D3A1FA90ED

P527

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

http://www.wikidata.org/entity/Q50299999

description

An instance of the biological ...... AB32 and RAB38 in Homo sapiens

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biologisch proces

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name

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

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type

label

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

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prefLabel

HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38

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BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles

BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor

Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes

The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes

Varp interacts with Rab38 and functions as its potential effector

Mutation of melanosome protein RAB38 in chocolate mice.

Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.

Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis.

Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes

Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.

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reactome:R-HSA-8877760

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biological process

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RAB GEFs exchange GTP for GDP on RABs

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R-HSA-8877760

http://www.w3.org/2001/XMLSchema#string

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guanosine triphosphate

guanosine 5'-diphosphate (RRSR form)

RAB32;RAB38:GDP:GDIs;CHMs

RAB32;RAB38:GTP

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