Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases.
about
Mutations within the propeptide, the primary cleavage site or the catalytic site, or deletion of C-terminal sequences, prevents secretion of proPC2 from transfected COS-7 cellsDifferences between the catalytic properties of recombinant human PC2 and endogenous rat PC2Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteinsIsolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytesFurin at the cutting edge: from protein traffic to embryogenesis and diseaseSubtilases: the superfamily of subtilisin-like serine proteasesImplication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptidesMechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not foldingActivation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavageA subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoitesStructural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site.A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3.cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinasesSubunit cleavage of mosquito pro-vitellogenin by a subtilisin-like convertase.Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system.Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide.Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme.Role of endoproteolytic dibasic proprotein processing in maturation of secretory proteins in Trichoderma reesei.Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step.Virus activation by host proteinases. A pivotal role in the spread of infection, tissue tropism and pathogenicity.In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor.Structural elements of PC2 required for interaction with its helper protein 7B2.Identification of a transferable sorting domain for the regulated pathway in the prohormone convertase PC2.Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases.Endoproteolytic processing of recombinant proalbumin variants by the yeast Kex2 protease.Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymesCloning and expression of gene encoding the thermostable direct hemolysin from Vibrio alginolyticus strain HY9901, the causative agent of vibriosis of crimson snapper (Lutjanus erythopterus).PACE4: a subtilisin-like endoprotease with unique properties.The contribution of arginine residues within the P6-P1 region of alpha 1-antitrypsin to its reaction with furin.Cloning and biochemical characterization of blisterase, a subtilisin-like convertase from the filarial parasite, Onchocerca volvulus.Structural investigation of the HIV-1 envelope glycoprotein gp160 cleavage site 3: role of site-specific mutations.In vitro characterization of the novel proprotein convertase PC7.Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin.Furin-independent pathway of membrane type 1-matrix metalloproteinase activation in rabbit dermal fibroblasts.PCSK6;FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimerCloning and expression of the gene encoding an extracellular alkaline serine protease from Vibrio alginolyticus strain HY9901, the causative agent of vibriosis in Lutjanus erythopterus (Bloch).
P2860
Q24318604-D73CBEB6-DEE6-472F-A3CC-724B94B29C7DQ24320289-9758DEB4-223A-4991-BADF-DEF27932173CQ24530571-754056DC-9ABE-4C38-A072-A9D0307E9E84Q24621842-D9FB5922-C109-499A-9C60-03659403355FQ24670432-592C40BA-358E-4730-B643-CDA01DB0AA26Q24673524-5DE31D2C-07C9-4741-9AB2-8642F1117654Q28347718-D487C7F4-DFE2-443F-A5CF-34BA662B37F7Q28507749-922114AA-9CC8-4979-AE33-583E7C26F7E3Q28941774-944E3360-5A8D-4456-B826-24B1596EE21CQ30043439-5F3783B5-6253-4E08-BEF9-BC90B0B44CF4Q30683183-8B51DD60-0916-47FC-A685-6EA520CBA48FQ30943394-9919A4AB-C4AA-4987-B661-25901504E14EQ34074254-D36DC496-01D3-4C55-9698-19C75352E7B3Q34649087-53592292-C221-4377-811E-008EE7ED245DQ36240699-718BC912-60B2-43CD-A94A-40C0E7C879B9Q36798204-B6C8FCC7-018C-441A-9BAF-11F712C25B92Q36801168-9EEC18E3-B04E-4CEE-A455-63CE533CD015Q37465249-8450C03D-2672-4872-ACAD-82652A353D9CQ37595180-6E043617-F053-43A4-A6D4-837BB5D2816FQ38312527-6B8A4498-764F-47D1-89B4-A84A74E0403BQ38316911-093F9820-BBEB-443C-AEF2-6E2E9FEBBBC3Q39563273-92BA8970-9FD1-4028-B24A-D4E2EA58982FQ40469066-F5C38D74-8D12-475B-857E-0F8D37BCE10AQ40546416-FDF9B3B3-15C9-4977-B9BE-0014C5EB6E52Q41043776-2CE1B42A-685B-4116-8DF0-B0C1B96130FBQ41066030-47A19A5D-689C-4866-9438-0EB91C94E724Q41159207-B3898BC5-9704-492A-917B-8714E7418C1FQ41295072-22475EE8-69F2-4080-8746-684E30911839Q42059288-9E1BA5AF-80A2-4D23-A98A-5FBE2B901F2EQ42097979-9D568D53-0178-4051-8C18-BCD705BAFB4FQ42626970-EC9AE7F5-2EC2-4937-9C37-8C57C8566426Q42985344-2CCED5EC-B3E5-4FB8-B368-3AEA6142B0E4Q43691933-FE731797-59F5-472F-9302-196A06FDA9E4Q44509791-22A292B3-4865-4F1B-B209-FF43CDC6C91EQ45139143-C738015F-B7C2-4A06-9F40-EF0900C76AE7Q45228205-099E4D34-F0B8-46A6-93B9-21EBB8E272F6Q47438129-281FD814-3435-436E-9EE2-1484C6775294Q47900415-A5E61C40-3FBF-476F-BE2F-3244C92B7BA1Q50299745-DC550E31-8276-44F7-A697-D804B70BCFEBQ54437758-48CD816E-FCD3-4938-837F-5BCA99FB9215
P2860
Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh-hant
name
Homology modelling of the cata ...... n-like proprotein convertases.
@en
Homology modelling of the cata ...... n-like proprotein convertases.
@nl
type
label
Homology modelling of the cata ...... n-like proprotein convertases.
@en
Homology modelling of the cata ...... n-like proprotein convertases.
@nl
prefLabel
Homology modelling of the cata ...... n-like proprotein convertases.
@en
Homology modelling of the cata ...... n-like proprotein convertases.
@nl
P2093
P2860
P1433
P1476
Homology modelling of the cata ...... n-like proprotein convertases.
@en
P2093
J W Creemers
R J Siezen
W J Van de Ven
P2860
P304
P356
10.1111/J.1432-1033.1994.TB18864.X
P407
P577
1994-06-01T00:00:00Z