Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.
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Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.Identification of the calcitonin receptor in osteoarthritic chondrocytes.Patients with rheumatoid arthritis have an altered circulatory aggrecan profile.Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments.Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytesProstaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinasesMeasurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation.Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model.Altered AIB1 or AIB1Δ3 expression impacts ERα effects on mammary gland stromal and epithelial contentCharacterization of an Ex vivo Femoral Head Model Assessed by Markers of Bone and Cartilage Turnover.The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.Radiological and biochemical effects (CTX-II, MMP-3, 8, and 13) of low-level laser therapy (LLLT) in chronic osteoarthritis in Al-Kharj, Saudi Arabia.Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure.High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment.Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases.Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor.Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study.Identification of progressors in osteoarthritis by combining biochemical and MRI-based markersBiochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development.Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration.Post-translational modifications of the extracellular matrix are key events in cancer progression: opportunities for biochemical marker development.Can β2-adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD?The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes.Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activityTemporal expression of calcium/calmodulin-dependent adenylyl cyclase isoforms in rat articular chondrocytes: RT-PCR and immunohistochemical localization.[Non-surgical treatment of osteoarthritis of large joints - new aspects].Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo.Exacerbation of Aging-Associated and Instability-Induced Murine Osteoarthritis With Deletion of D Prostanoid Receptor 1, a Prostaglandin D2 Receptor.The association of single nucleotide polymorphisms in the calcitonin gene with primary osteoarthritis of the knee in Mexican mestizo population.Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes.
P2860
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P2860
Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Induction of increased cAMP le ...... ediated cartilage degradation.
@en
Induction of increased cAMP le ...... ediated cartilage degradation.
@nl
type
label
Induction of increased cAMP le ...... ediated cartilage degradation.
@en
Induction of increased cAMP le ...... ediated cartilage degradation.
@nl
prefLabel
Induction of increased cAMP le ...... ediated cartilage degradation.
@en
Induction of increased cAMP le ...... ediated cartilage degradation.
@nl
P2093
P356
P1476
Induction of increased cAMP le ...... mediated cartilage degradation
@en
P2093
Bodil-Cecilie Sondergaard
Claus Christiansen
Eren Ufuk Sumer
Helle Wulf
Morten Asser Karsdal
Suzi H Madsen
P2860
P304
P356
10.1002/ART.22599
P577
2007-05-01T00:00:00Z