sameAs
Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domainMatrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan.ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritisBlocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairEvidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active OligomersMast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogensDrug insight: aggrecanases as therapeutic targets for osteoarthritis.Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?Identifying the human aggrecanase.Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2.Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activityBrief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.Transparency Is the Key to Quality.Matrix metalloproteinases are active following guanidine hydrochloride extraction of cartilage: generation of DIPEN neoepitope during dialysis.Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.Reduction of arthritis severity in protease-activated receptor-deficient mice.N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse.The role of hepatocyte growth factor in the humoral regulation of inguinal hernia closure.Changes in versican and chondroitin sulfate proteoglycans during structural development of the lung.Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease.ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors.Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved AggrecanTo clot or notThe sulphation pattern in chondroitin sulphate chains investigated by chondroitinase ABC and ACII digestion and reactivity with monoclonal antibodiesADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5Connective tissue remodelling in the ovine cervix during pregnancy and at termDegradation of cartilage aggrecan by collagenase-3 (MMP-13)
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P50
description
Australian biomedical researcher
@en
Investigadora biomédica australiana
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chercheuse en bio-médecine
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wetenschapster uit Australië
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name
Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda J. Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda J. Fosang
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Amanda J. Fosang
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Amanda J. Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda Fosang
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Amanda J. Fosang
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1950-01-01T00:00:00Z
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lccn-n2003145941