about
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKLLoss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome primingADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairAnalysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.New insights into the regulation of innate immunity by caspase-8.Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan.Critical role for granulocyte colony-stimulating factor in inflammatory arthritis.Caspase-8: not so silently deadly.Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling.Distinctive pro-inflammatory gene signatures induced in articular chondrocytes by oncostatin M and IL-6 are regulated by Suppressor of Cytokine Signaling-3.XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretionAcute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor.CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation.IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1β Secretion.IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.FcγRIIb controls bone marrow plasma cell persistence and apoptosisKey Role of Suppressor of Cytokine Signaling 3 in Regulating gp130 Cytokine-Induced Signaling and Limiting Chondrocyte Responses During Murine Inflammatory ArthritiscIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent mannerBcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasisThe Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β ActivationThe pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophilsTherapeutic Effects of a TANK-Binding Kinase 1 Inhibitor in Germinal Center-Driven Collagen-Induced ArthritisEvaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritisMolecular and cellular mediators of interleukin-1-dependent acute inflammatory arthritisDie Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death
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P50
description
hulumtuese
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researcher
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wetenschapper
@nl
հետազոտող
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name
Kate E Lawlor
@nl
Kate E Lawlor
@sl
Kate E. Lawlor
@en
Kate E. Lawlor
@es
type
label
Kate E Lawlor
@nl
Kate E Lawlor
@sl
Kate E. Lawlor
@en
Kate E. Lawlor
@es
prefLabel
Kate E Lawlor
@nl
Kate E Lawlor
@sl
Kate E. Lawlor
@en
Kate E. Lawlor
@es
P106
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10041545200
P21
P31
P496
0000-0003-0471-6842