LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. - Wikidata - wikimedia - TriplyDB

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

http://www.wikidata.org/entity/Q50781580

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NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming Lin28 and let-7 in cell metabolism and cancer Cell Proliferation in Neuroblastoma Chemoresistance, cancer stem cells, and miRNA influences: the case for neuroblastoma The role of miRNAs in regulating gene expression networks Epigenetic deregulation of microRNAs in rhabdomyosarcoma and neuroblastoma and translational perspectives MicroRNA biogenesis pathways in cancer The zebrafish as a model for studying neuroblastoma Focal DNA copy number changes in neuroblastoma target MYCN regulated genes Lin28: primal regulator of growth and metabolism in stem cells Lin28 sustains early renal progenitors and induces Wilms tumor Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology.The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.Comparison of the gene expression profiles of human fetal cortical astrocytes with pluripotent stem cell derived neural stem cells identifies human astrocyte markers and signaling pathways and transcription factors active in human astrocytes 11q deletion in neuroblastoma: a review of biological and clinical implications.Research progress of neuroblastoma related gene variations.The prenatal origins of cancer RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma Therapeutic targets for neuroblastomas.A cell-based high-throughput screen addressing 3'UTR-dependent regulation of the MYCN gene.MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma.Neuroblastoma: developmental biology, cancer genomics and immunotherapy.Neuroblastoma: molecular pathogenesis and therapy.LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.Identification of small molecule inhibitors of Zcchc11 TUTase activity.The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy MYCN-targeting miRNAs are predominantly downregulated during MYCN‑driven neuroblastoma tumor formation.A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies.DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma--differences in histological subtypes A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression.The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis.Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.The Lin28/let-7 axis is critical for myelination in the peripheral nervous system.Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.

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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

http://www.wikidata.org/entity/Q50781580

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

@wuu

2012年学术文章

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2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh-hant

name

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

@en

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

@nl

type

label

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

@en

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

@nl

prefLabel

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

@en

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

@nl

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Nature Genetics

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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

@en

P2093

Alexander Schramm

http://www.w3.org/2001/XMLSchema#string

Angelika Eggert

http://www.w3.org/2001/XMLSchema#string

Annika Sprüssel

http://www.w3.org/2001/XMLSchema#string

Franciska Haneveld

http://www.w3.org/2001/XMLSchema#string

Huib N Caron

http://www.w3.org/2001/XMLSchema#string

Isabella Bray

http://www.w3.org/2001/XMLSchema#string

Jan J Molenaar

http://www.w3.org/2001/XMLSchema#string

Johan van Nes

http://www.w3.org/2001/XMLSchema#string

Johannes H Schulte

http://www.w3.org/2001/XMLSchema#string

Kristina Kieckbusch

http://www.w3.org/2001/XMLSchema#string

P2860

The nuclear RNase III Drosha initiates microRNA processing

Cytohesins are cytoplasmic ErbB receptor activators

Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

MicroRNA maturation: stepwise processing and subcellular localization.

Selective blockade of microRNA processing by Lin28

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.

The Lin28/let-7 axis regulates glucose metabolism

Genetic variation in LIN28B is associated with the timing of puberty

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

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1199-1206

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scholarly article

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10.1038/NG.2436

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P433

11

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44

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Jo Vandesompele

Rogier Versteeg

Lukas C Heukamp

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2012-10-07T00:00:00Z

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P5875

232066128

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P698

23042116

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