Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis. - Wikidata - wikimedia - TriplyDB

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q50932808

about

Altered ribostasis: RNA-protein granules in degenerative disorders Inside out: the role of nucleocytoplasmic transport in ALS and FTLD Copy Number Variations in the Survival Motor Neuron Genes: Implications for Spinal Muscular Atrophy and Other Neurodegenerative Diseases Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Neuronal RNA-binding proteins in health and disease ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.Nuclear localization of SMN and FUS is not altered in fibroblasts from patients with sporadic ALS Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants Minor splicing pathway is not minor any more: implications for the pathogenesis of motor neuron diseases.RNA metabolism in ALS: when normal processes become pathological.Gem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.Targeting TDP-43 in neurodegenerative diseases.Developing therapies for spinal muscular atrophy.Old versus New Mechanisms in the Pathogenesis of ALS.Cajal bodies in neurons Distinct pathways leading to TDP-43-induced cellular dysfunctions.Linking amyotrophic lateral sclerosis and spinal muscular atrophy through RNA-transcriptome homeostasis: a genomics perspective.Faulty RNA splicing: consequences and therapeutic opportunities in brain and muscle disorders.Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.U6 snRNA expression prevents toxicity in TDP-43-knockdown cells.Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis.De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies.Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice.Variant snRNPs: New players within the spliceosome system.Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

P2860

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P2860

Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q50932808

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

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2013年學術文章

@yue

2013年學術文章

@zh-hant

name

Decreased number of Gemini of ...... amyotrophic lateral sclerosis.

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Decreased number of Gemini of ...... amyotrophic lateral sclerosis.

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type

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Decreased number of Gemini of ...... amyotrophic lateral sclerosis.

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Decreased number of Gemini of ...... amyotrophic lateral sclerosis.

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Decreased number of Gemini of ...... amyotrophic lateral sclerosis.

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Decreased number of Gemini of ...... amyotrophic lateral sclerosis.

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P356

P1433

Human Molecular Genetics

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Decreased number of Gemini of ...... amyotrophic lateral sclerosis

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P2093

Akihide Koyama

http://www.w3.org/2001/XMLSchema#string

Akio Yokoseki

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Akiyoshi Kakita

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Atsushi Shiga

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Chun-Feng Tan

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Hitoshi Takahashi

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Mariko Yokoo

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Masatoyo Nishizawa

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Taisuke Kato

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Takeshi Fujino

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P2860

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

Higher order arrangement of the eukaryotic nuclear bodies.

Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I

Coiled bodies preferentially associate with U4, U11, and U12 small nuclear RNA genes in interphase HeLa cells but not with U6 and U7 genes

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

U12DB: a database of orthologous U12-type spliceosomal introns

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments

Splicing of a rare class of introns by the U12-dependent spliceosome

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4136-4147

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10.1093/HMG/DDT262

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20

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22

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Tomohiko Ishihara

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2013-06-04T00:00:00Z

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237060708

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23740936

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amyotrophic lateral sclerosis

small nuclear RNA