Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.
about
PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21Structural insights into the transcription-independent apoptotic pathway of p53The DNA-binding domain mediates both nuclear and cytosolic functions of p53Solution structure and binding specificity of the p63 DNA binding domainHigh Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain.GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria.IIIDB: a database for isoform-isoform interactions and isoform network modules.Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinomaHepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondriaDual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domainMyc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosisOroxylin A modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53.The p53 family and programmed cell deathThe mitochondrial p53 pathway.Cytoplasmic functions of the tumour suppressor p53.A conserved mechanism for binding of p53 DNA-binding domain and anti-apoptotic Bcl-2 family proteins.The relevance of protein-protein interactions for p53 function: the CPE contribution.Driving apoptosis-relevant proteins toward neural differentiation.Many players in BCL-2 family affairs.The cytoplasmic side of p53's oncosuppressive activities.A Novel Naphthalimide Compound Restores p53 Function in Non-small Cell Lung Cancer by Reorganizing the Bak·Bcl-xl Complex and Triggering Transcriptional Regulation.The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression.Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xLMitochondrial death functions of p53.Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase.Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process
P2860
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P2860
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Comparative biophysical charac ...... and the anti-apoptotic BCL-xL.
@en
Comparative biophysical charac ...... and the anti-apoptotic BCL-xL.
@nl
type
label
Comparative biophysical charac ...... and the anti-apoptotic BCL-xL.
@en
Comparative biophysical charac ...... and the anti-apoptotic BCL-xL.
@nl
prefLabel
Comparative biophysical charac ...... and the anti-apoptotic BCL-xL.
@en
Comparative biophysical charac ...... and the anti-apoptotic BCL-xL.
@nl
P2860
P356
P1476
Comparative biophysical charac ...... and the anti-apoptotic BCL-xL.
@en
P2093
Begona Sot
Stefan M V Freund
P2860
P304
29193-29200
P356
10.1074/JBC.M705544200
P407
P50
P577
2007-08-14T00:00:00Z