Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.
about
Nucleic Acid aptamers: new methods for selection, stabilization, and application in biomedical scienceCD28 co-stimulation in T-cell homeostasis: a recent perspectiveIndividual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.Ex vivo assays of dendritic cell activation and cytokine profiles as predictors of in vivo effects in an anti-human CD40 monoclonal antibody ChiLob 7/4 phase I trialAfter TGN1412: recent developments in cytokine release assays.Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells.Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cellsAnti-CD28 Antibody-Initiated Cytokine Storm in Canines.Defining the critical hurdles in cancer immunotherapy.TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse ModelFailure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individualsComparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal ModelsModeling Ischemic Stroke In Vitro: Status Quo and Future Perspectives.Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies.Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine stormCD28 aptamers as powerful immune response modulatorsSeverity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion.Dendritic cells enhance the antigen sensitivity of T cells.B7 family checkpoint regulators in immune regulation and disease.Stabilizing human regulatory T cells for tolerance inducing immunotherapy.Cytokines: The Good, the Bad, and the Deadly.Delivering safer immunotherapies for cancer.The storm has cleared: lessons from the CD28 superagonist TGN1412 trial.A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.TCR signalling network organization at the immunological synapses of murine regulatory T cells.The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account.A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T Cells.Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells.Virtual Global Transplant Laboratory Standard Operating Procedures for Blood Collection, PBMC Isolation, and Storage.Improvement of IFNg ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis.Modulation of heme oxygenase-1 by metalloporphyrins increases anti-viral T cell responses.NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways.Materials design at the interface of nanoparticles and innate immunity.Guidelines for the use of flow cytometry and cell sorting in immunological studies.The role of CD4(+) T cells in BKV-specific T cell immunity.Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08.Generation and preclinical characterization of an antibody specific for SEMA4D.The return of the prodigal son and the extraordinary development route of antibody TGN1412 - lessons for drug development and clinical pharmacology.
P2860
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P2860
Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Preculture of PBMCs at high ce ...... by CD28 superagonist TGN1412.
@en
Preculture of PBMCs at high ce ...... by CD28 superagonist TGN1412.
@nl
type
label
Preculture of PBMCs at high ce ...... by CD28 superagonist TGN1412.
@en
Preculture of PBMCs at high ce ...... by CD28 superagonist TGN1412.
@nl
prefLabel
Preculture of PBMCs at high ce ...... by CD28 superagonist TGN1412.
@en
Preculture of PBMCs at high ce ...... by CD28 superagonist TGN1412.
@nl
P2093
P50
P1433
P1476
Preculture of PBMCs at high ce ...... by CD28 superagonist TGN1412.
@en
P2093
Ineke ten Berge
Paula S Römer
Shin-Young Na
Susanne Berr
Thomas Hünig
P304
P356
10.1182/BLOOD-2010-12-319780
P407
P577
2011-09-19T00:00:00Z