The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
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Identification of putative potassium channel homologues in pathogenic protozoaPharmacological inhibition of IK1 by PA-6 in isolated rat hearts affects ventricular repolarization and refractorinessDiscovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1.Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics.The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells.Molecular determinants of pentamidine-induced hERG trafficking inhibition.Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion ChannelInhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference.KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmiaPentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.Old friends in new guise: repositioning of known drugs with structural bioinformatics.Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium ChannelsInhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.Inhibition of Kir4.1 potassium channels by quinacrine.Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.
P2860
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P2860
The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The anti-protozoal drug pentam ...... ic pore region of the channel.
@ast
The anti-protozoal drug pentam ...... ic pore region of the channel.
@en
type
label
The anti-protozoal drug pentam ...... ic pore region of the channel.
@ast
The anti-protozoal drug pentam ...... ic pore region of the channel.
@en
prefLabel
The anti-protozoal drug pentam ...... ic pore region of the channel.
@ast
The anti-protozoal drug pentam ...... ic pore region of the channel.
@en
P2093
P2860
P50
P1476
The anti-protozoal drug pentam ...... mic pore region of the channel
@en
P2093
B L de Groot
J D M Beekman
M J C Houtman
T A B van Veen
P2860
P304
P356
10.1111/J.1476-5381.2010.00658.X
P407
P577
2010-02-24T00:00:00Z