A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.
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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptorsGlucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors.Comparison of the physiological relevance of systemic vs. portal insulin delivery to evaluate whole body glucose flux during an insulin clampDefective glycogenesis contributes toward the inability to suppress hepatic glucose production in response to hyperglycemia and hyperinsulinemia in zucker diabetic fatty ratsCorrelation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes.Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats.Molecular targeting of the GK-GKRP pathway in diabetes.Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein.Targeting hepatic glucokinase in type 2 diabetes: weighing the benefits and risks.Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis.Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle.For the ZDF rat, "Breaking up is hard to do": dissociation of the GK:GKRP complex.
P2860
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P2860
A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
@wuu
2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
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2007年學術文章
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2007年學術文章
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name
A defect in glucose-induced di ...... n the early stage of diabetes.
@en
A defect in glucose-induced di ...... n the early stage of diabetes.
@nl
type
label
A defect in glucose-induced di ...... n the early stage of diabetes.
@en
A defect in glucose-induced di ...... n the early stage of diabetes.
@nl
prefLabel
A defect in glucose-induced di ...... n the early stage of diabetes.
@en
A defect in glucose-induced di ...... n the early stage of diabetes.
@nl
P2093
P2860
P1476
A defect in glucose-induced di ...... in the early stage of diabetes
@en
P2093
E P Donahue
Masakazu Shiota
Reetta L Catlin
Tracy P Torres
P2860
P304
P356
10.1152/AJPREGU.00260.2006
P577
2007-01-04T00:00:00Z