Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1. - Wikidata - wikimedia - TriplyDB

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

http://www.wikidata.org/entity/Q51839904

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The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1.Rho GTPase regulation by miRNAs and covalent modifications The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity.Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation.Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)Rac1 dynamics in the human opportunistic fungal pathogen Candida albicans The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin.Nuclear Rac1 regulates the bFGF-induced neurite outgrowth in PC12 cells.Splice variants of SmgGDS control small GTPase prenylation and membrane localization Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation.Suppression of nuclear Wnt signaling leads to stabilization of Rac1 isoforms.SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma.SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer.Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells.Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors.Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import Phosphorylation and isoform use in p120-catenin during development and tumorigenesis Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases Looking beyond the Wnt pathway for the deep nature of β-catenin.Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors The Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of β1PIX with β-catenin.Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin.The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.The C-terminal region of E1A: a molecular tool for cellular cartography.Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression.Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding.Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.Phosphorylation of Rac1 T108 by extracellular signal-regulated kinase in response to epidermal growth factor: a novel mechanism to regulate Rac1 function Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells.

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P2860

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

http://www.wikidata.org/entity/Q51839904

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

@en

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

@nl

type

label

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

@en

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

@nl

prefLabel

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

@en

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

@nl

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P1476

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

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P2093

Carol L Williams

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Cathy Cole Lanning

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Rebecca Ruiz-Velasco

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P2860

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

Asef, a link between the tumor suppressor APC and G-protein signaling

Localized Rac activation dynamics visualized in living cells

Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide

SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase

Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression

Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element

Karyopherins and nuclear import

A repeating amino acid motif shared by proteins with diverse cellular roles

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10.1074/JBC.M211286200

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