Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
about
The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein UnkemptNaturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitorsYersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1.Rho GTPase regulation by miRNAs and covalent modificationsThe Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity.Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation.Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)Rac1 dynamics in the human opportunistic fungal pathogen Candida albicansThe small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signalsThe 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin.Nuclear Rac1 regulates the bFGF-induced neurite outgrowth in PC12 cells.Splice variants of SmgGDS control small GTPase prenylation and membrane localizationCross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation.Suppression of nuclear Wnt signaling leads to stabilization of Rac1 isoforms.SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma.SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer.Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells.Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors.Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear importPhosphorylation and isoform use in p120-catenin during development and tumorigenesisRac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPasesLooking beyond the Wnt pathway for the deep nature of β-catenin.Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factorsThe Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of β1PIX with β-catenin.Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin.The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.The C-terminal region of E1A: a molecular tool for cellular cartography.Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression.Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding.Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.Phosphorylation of Rac1 T108 by extracellular signal-regulated kinase in response to epidermal growth factor: a novel mechanism to regulate Rac1 functionRap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neckRac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells.
P2860
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P2860
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
@en
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
@nl
type
label
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
@en
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
@nl
prefLabel
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
@en
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
@nl
P2093
P2860
P356
P1476
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
@en
P2093
Carol L Williams
Cathy Cole Lanning
Rebecca Ruiz-Velasco
P2860
P304
12495-12506
P356
10.1074/JBC.M211286200
P407
P577
2003-01-27T00:00:00Z