Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354.
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Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin DimersApplying an empirical hydropathic forcefield in refinement may improve low-resolution protein X-ray crystal structuresDocking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analoguesMolecular basis for fungal selectivity of novel antimitotic compounds.Design and synthesis of a focused library of novel aryl- and heteroaryl-ketopiperazides.Design, synthesis, and biological evaluation of stable colchicine binding site tubulin inhibitors as potential anticancer agents.Interactions of antimitotic peptides and depsipeptides with tubulin.Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates.Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity.An overview of tubulin inhibitors that interact with the colchicine binding siteThe tubulin colchicine domain: a molecular modeling perspective.Novel mutations involving βI-, βIIA-, or βIVB-tubulin isotypes with functional resemblance to βIII-tubulin in breast cancer.Comparative analyses of the β-tubulin gene and molecular modeling reveal molecular insight into the colchicine resistance in kinetoplastids organisms.Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12.Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.Analysis of β-tubulin-carbendazim interaction reveals that binding site for MBC fungicides does not include residues involved in fungicide resistance.
P2860
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P2860
Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354.
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2000 nî lūn-bûn
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Mapping the binding site of co ...... secondarily with cysteine 354.
@en
Mapping the binding site of co ...... secondarily with cysteine 354.
@nl
type
label
Mapping the binding site of co ...... secondarily with cysteine 354.
@en
Mapping the binding site of co ...... secondarily with cysteine 354.
@nl
prefLabel
Mapping the binding site of co ...... secondarily with cysteine 354.
@en
Mapping the binding site of co ...... secondarily with cysteine 354.
@nl
P2093
P2860
P356
P1476
Mapping the binding site of co ...... secondarily with cysteine 354.
@en
P2093
P2860
P304
40443-40452
P356
10.1074/JBC.M005299200
P407
P577
2000-12-01T00:00:00Z