Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.
about
Altered T cell activation and development in transgenic mice expressing the HIV-1 nef geneRapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.Intrathymic maturation of murine T lymphocytes from CD8+ precursorsWithout peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation.Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development.GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulationEngagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cellsHD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells.Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selectionDisruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4(+) T cells in vivoDecreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytesCD4/immunoglobulin interaction: implications for immune physiology and autoimmunity.Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes.A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking: implications for repertoire selection in the thymus.
P2860
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P2860
Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh-hant
name
Engagement of the CD4 molecule ...... T-cell receptor on thymocytes.
@en
Engagement of the CD4 molecule ...... T-cell receptor on thymocytes.
@nl
type
label
Engagement of the CD4 molecule ...... T-cell receptor on thymocytes.
@en
Engagement of the CD4 molecule ...... T-cell receptor on thymocytes.
@nl
prefLabel
Engagement of the CD4 molecule ...... T-cell receptor on thymocytes.
@en
Engagement of the CD4 molecule ...... T-cell receptor on thymocytes.
@nl
P2093
P356
P1433
P1476
Engagement of the CD4 molecule ...... T-cell receptor on thymocytes.
@en
P2093
Kruisbeek AM
McCarthy SA
Sharrow SO
Uppenkamp IK
P2888
P356
10.1038/336076A0
P407
P577
1988-11-01T00:00:00Z
P6179
1012795029