Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.
about
Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strandThe Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signalingCD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.Impairment of T cell development in deltaEF1 mutant miceDisruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinaseFunctional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicityITAM-mediated signaling by the T-cell antigen receptorThe CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages.Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.Gamma delta T cells recognize haptens and mount a hapten-specific response.Decreased expression of the CD3zeta chain in T cells infiltrating the synovial membrane of patients with osteoarthritis.T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.Challenges and future perspectives of T cell immunotherapy in cancerDevelopment and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma.HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells.Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage.Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor.Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiationIntestinal intraepithelial lymphocytes: the plot thickens.Delayed maturation of CD4- CD8- Fc gamma RII/III+ T and natural killer cell precursors in Fc epsilon RI gamma transgenic mice.An endoplasmic reticulum retention function for the cytoplasmic tail of the human pre-T cell receptor (TCR) alpha chain: potential role in the regulation of cell surface pre-TCR expression levels.Constitutive endocytosis and degradation of the pre-T cell receptor.Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire.T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma).One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop.Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses.Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidneyTargeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mousec-Myb regulates the proliferation of immature thymocytes following beta-selection.Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia.Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice.Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex.High frequency of cancer patients with abnormal assembly of the T cell receptor-CD3 complex in peripheral blood T lymphocytes.
P2860
Q28513949-6408784D-484B-4EAE-936C-532CD9573884Q28586244-DD118071-65F2-4A73-BC35-D94AF6810DB1Q28589169-0302C4F5-350F-4DA0-BF32-67821DE59339Q28591826-A0BC005D-6865-4BD2-9EFE-448B73B82A4CQ28593717-13CB6D5E-F79B-4CD1-9CD0-545D31878B7AQ28610853-C197DCE2-4812-4EEE-A87A-9C879567AA13Q33849367-8271148D-44DA-498F-9E96-7588F2F79C44Q33888549-2CF23FC7-4474-48E4-BB3B-49D58765DD9DQ34054352-600E5C0D-19C8-4AB2-A09E-3028D315299AQ34241427-C13359C4-7483-418F-8B13-A99F47AF63C8Q35541642-D67CB618-6A39-426E-81F0-2F8A230966F9Q35751012-842AAC3E-2541-401D-87CC-DE9805C8F993Q35843507-75F2846F-13F0-48EA-8B16-0BC8D2EF4C83Q35958038-03EB1ECE-9EB5-4ED7-A7D4-97D16CDBFB49Q36171328-E0723407-7910-4497-87F0-3FCDB51020B4Q36261425-C8E82126-1320-4FDE-AFA7-FD228EC5DB95Q36322693-934F3C1D-1648-45A4-849C-64A2BB0E5540Q36363567-C01E23A3-1829-4885-9888-0DA811A92E83Q36363865-85F5E132-EE1D-4631-846E-E79A20F3F5D9Q36367518-2BC900B1-A7FA-4C7A-A8C3-266576771A73Q36369314-B6A48617-2970-4861-9B9F-56496C5EA879Q36369757-E880788B-E1D9-4DC2-8093-55AE1E3241A4Q36376884-7C5752D6-CD8E-41FF-80CD-5E5A5261DB25Q36400581-5804EC79-253E-4F74-9AF0-9999E482A665Q36400745-F5BACC09-70CA-43C8-89A8-1739E0013E75Q36688308-3570FD63-EBE2-49A0-A74E-ED5A8A3E40B1Q37380253-EAC57D52-1B60-468E-B303-02B7EE969052Q37387592-F3D54C20-88F2-483E-9AFB-58CB9DEA09D1Q37622301-186C529D-D5E7-4143-A47E-C73DBF6EA171Q37628748-A72F6372-5E18-43D9-9E1F-32BE6AD7B3D2Q40388168-1D939FAE-855F-438D-AC8E-D9F8FE8D093CQ41788651-A906D57F-3B72-43D7-A534-709821F24B88Q42062476-E4C86488-78D7-4C16-85CA-41410BACC656Q42942951-746E9C35-2DD9-4AB9-BD28-D194912F1B66Q55195444-48A4F270-06C3-41BB-9D89-7D15C245128E
P2860
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.
@en
type
label
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.
@en
prefLabel
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.
@en
P2093
P2860
P1433
P1476
Developmental and functional impairment of T cells in mice lacking CD3 zeta chains
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1993.TB06120.X
P407
P577
1993-11-01T00:00:00Z