Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin.
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Scorpion toxin block of the early K+ current (IKf) in rat dorsal root ganglion neuronesElectrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels.Brownian dynamics simulations of interaction between scorpion toxin Lq2 and potassium ion channel.Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomesChemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxinsPeptide toxins and small-molecule blockers of BK channelsScorpion toxins specific for potassium (K+) channels: a historical overview of peptide bioengineeringSolution structure of the major alpha-amylase inhibitor of the crop plant amaranthNew binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.Mechanism of charybdotoxin block of a voltage-gated K+ channel.A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and localization in rat brain.Scorpion toxins as natural scaffolds for protein engineeringElectrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2)A subfamily of acidic alpha-K(+) toxins.Plant alpha-amylase inhibitors and their interaction with insect alpha-amylases.Binding modes of μ-conotoxin to the bacterial sodium channel (NaVAb)Electrostatic distance geometry in a K+ channel vestibule.Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1Permeation and block of the Kv1.2 channel examined using brownian and molecular dynamics.Modeling the binding of three toxins to the voltage-gated potassium channel (Kv1.3)The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin.Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage displayMolecular surface of tarantula toxins interacting with voltage sensors in K(v) channelsmu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels.Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channelAcid-sensing ion channels interact with and inhibit BK K+ channels.Stabilization of the conductive conformation of a voltage-gated K+ (Kv) channel: the lid mechanismK(+) channels: function-structural overview.Voltage dependence of the Ca(2+)-activated K(+) channel K(Ca)3.1 in human erythroleukemia cells.Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels.Simulation of the interaction between ScyTx and small conductance calcium-activated potassium channel by docking and MM-PBSA.Influence of the membrane potential on the free energy of an intrinsic protein.Mechanism of maxi-K channel activation by dehydrosoyasaponin-I.Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch.A provisional transport mechanism for a chloride channel-type Cl-/H+ exchanger.A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom.Fast single-channel measurements resolve the blocking effect of Cs+ on the K+ channel.
P2860
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P2860
Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh-hant
name
Mapping function to structure ...... atic mutants of charybdotoxin.
@en
Mapping function to structure ...... atic mutants of charybdotoxin.
@nl
type
label
Mapping function to structure ...... atic mutants of charybdotoxin.
@en
Mapping function to structure ...... atic mutants of charybdotoxin.
@nl
prefLabel
Mapping function to structure ...... atic mutants of charybdotoxin.
@en
Mapping function to structure ...... atic mutants of charybdotoxin.
@nl
P356
P1433
P1476
Mapping function to structure ...... atic mutants of charybdotoxin.
@en
P2093
P304
P356
10.1021/BI00149A002
P407
P577
1992-09-01T00:00:00Z