Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling.
about
Structure of human follicle-stimulating hormone in complex with its receptorNew Frontier in Glycoprotein Hormones and Their Receptors Structure-FunctionTyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information.Hormone interactions to Leu-rich repeats in the gonadotropin receptors. I. Analysis of Leu-rich repeats of human luteinizing hormone/chorionic gonadotropin receptor and follicle-stimulating hormone receptor.The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation.The luteinizing hormone receptor: insights into structure-function relationships and hormone-receptor-mediated changes in gene expression in ovarian cancer cells.Functional differences of invariant and highly conserved residues in the extracellular domain of the glycoprotein hormone receptorsExtended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster.Structure, function and regulation of gonadotropin receptors - a perspective.Structure-function relationships of the luteinizing hormone receptor.A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.Evidence for cooperative signal triggering at the extracellular loops of the TSH receptorThe superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity.Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.Orientation of follicle-stimulating hormone (FSH) subunits complexed with the FSH receptor. Beta subunit toward the N terminus of exodomain and alpha subunit to exoloop 3.Two defective heterozygous luteinizing hormone receptors can rescue hormone action.The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. II. Photoaffinity labeling.The amino-terminal region of the luteinizing hormone/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. I. Mutational analysis.Protein engineering of a novel constitutively active hormone-receptor complex.Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.Studies on the relevance of the glycan at Asn-52 of the alpha-subunit of human chorionic gonadotropin in the alphabeta dimer.Hormone-induced conformational change of the purified soluble hormone binding domain of follitropin receptor complexed with single chain follitropin.Structural requirements for mutational lutropin/choriogonadotropin receptor activation.Hormone interactions to Leu-rich repeats in the gonadotropin receptors. II. Analysis of Leu-rich repeat 4 of human luteinizing hormone/chorionic gonadotropin receptor.Autologous biological response modification of the gonadotropin receptor.Ligand selectivity of gonadotropin receptors. Role of the beta-strands of extracellular leucine-rich repeats 3 and 6 of the human luteinizing hormone receptor.Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity.The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population.
P2860
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P2860
Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Determination of residues impo ...... cted mutagenesis and modeling.
@en
Determination of residues impo ...... cted mutagenesis and modeling.
@nl
type
label
Determination of residues impo ...... cted mutagenesis and modeling.
@en
Determination of residues impo ...... cted mutagenesis and modeling.
@nl
prefLabel
Determination of residues impo ...... cted mutagenesis and modeling.
@en
Determination of residues impo ...... cted mutagenesis and modeling.
@nl
P2093
P356
P1476
Determination of residues impo ...... cted mutagenesis and modeling.
@en
P2093
P304
P356
10.1210/ME.10.9.1147
P577
1996-09-01T00:00:00Z