Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity.
about
Structure of human follicle-stimulating hormone in complex with its receptorBinding site for Robo receptors revealed by dissection of the leucine-rich repeat region of SlitNew insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7How genetic errors in GPCRs affect their function: Possible therapeutic strategiesMutations in a novel, cryptic exon of the luteinizing hormone/chorionic gonadotropin receptor gene cause male pseudohermaphroditismStructural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkFemale mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excessThyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activationThyrotropin receptor-associated diseases: from adenomata to Graves diseaseThe luteinizing hormone receptor: insights into structure-function relationships and hormone-receptor-mediated changes in gene expression in ovarian cancer cells.Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptorFunctional differences of invariant and highly conserved residues in the extracellular domain of the glycoprotein hormone receptorsExtended and structurally supported insights into extracellular hormone binding, signal transduction and organization of the thyrotropin receptor.Evidence that the thyroid-stimulating hormone (TSH) receptor transmembrane domain influences kinetics of TSH binding to the receptor ectodomain.Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structureRadiological illustration of spontaneous ovarian hyperstimulation syndrome.Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians.A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism.An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction.A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties.Evidence for cooperative signal triggering at the extracellular loops of the TSH receptorNovel insights on thyroid-stimulating hormone receptor signal transduction.A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domainAnticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor.Model of glycoprotein hormone receptor ligand binding and signaling.Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.Follitropin receptors contain cryptic ligand binding sites.Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity.An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.Thyreotropic effect of human Chorionic Gonadotropin (hCG) in mares at estrus.The Exonization and Functionalization of an Alu-J Element in the Protein Coding Region of Glycoprotein Hormone Alpha Gene Represent a Novel Mechanism to the Evolution of Hemochorial Placentation in Primates.Cloning and expression analysis of follicle-stimulating hormone and luteinizing hormone receptor during the reproductive cycle in Korean rockfish (Sebastes schlegeli).
P2860
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P2860
Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Glycoprotein hormone receptors ...... nsible for ligand specificity.
@en
Glycoprotein hormone receptors ...... nsible for ligand specificity.
@nl
type
label
Glycoprotein hormone receptors ...... nsible for ligand specificity.
@en
Glycoprotein hormone receptors ...... nsible for ligand specificity.
@nl
prefLabel
Glycoprotein hormone receptors ...... nsible for ligand specificity.
@en
Glycoprotein hormone receptors ...... nsible for ligand specificity.
@nl
P2093
P2860
P50
P356
P1433
P1476
Glycoprotein hormone receptors ...... nsible for ligand specificity.
@en
P2093
Christine Richter
Cédric Govaerts
Gilbert Vassart
Sabine Costagliola
Véronique Janssens
P2860
P304
P356
10.1093/EMBOJ/CDG260
P407
P577
2003-06-01T00:00:00Z