Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
about
Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosisIdentification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinolIdentification of all-trans-retinol:all-trans-13,14-dihydroretinol saturaseA mitochondrial enzyme degrades carotenoids and protects against oxidative stressRPE65 is the isomerohydrolase in the retinoid visual cycleRetinoid-binding proteins: mediators of retinoid actionOpsin activation of transduction in the rods of dark-reared Rpe65 knockout miceTreatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trialRetinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectivelyThe emerging roles of melanopsin in behavioral adaptation to lightSafety and efficacy of gene transfer for Leber's congenital amaurosisNovel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluationsNinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptidePalmitoyl transferase activity of lecithin retinol acyl transferaseRecombinant adeno-associated virus type 2-mediated gene delivery into the Rpe65-/- knockout mouse eye results in limited rescuePharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis.Noninvasive two-photon imaging reveals retinyl ester storage structures in the eyeGenetic manipulation for inherited neurodegenerative diseases: myth or reality?Lipid Nanoparticles for Ocular Gene DeliveryAAV-mediated gene therapy in mouse models of recessive retinal degenerationA comprehensive review of retinal gene therapyConstitutively active rhodopsin and retinal diseaseSignal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cellsCLRN1 is nonessential in the mouse retina but is required for cochlear hair cell developmentIdentification of a common non-apoptotic cell death mechanism in hereditary retinal degenerationBicistronic lentiviruses containing a viral 2A cleavage sequence reliably co-express two proteins and restore vision to an animal model of LCA1Importance of Membrane Structural Integrity for RPE65 Retinoid Isomerization ActivityIntrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions.Molecular Basis for Vitamin A Uptake and Storage in VertebratesBiology and therapy of inherited retinal degenerative disease: insights from mouse modelsIdentification of RPE65 in transformed kidney cellsRetinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt diseaseMolecular cloning of a novel lipocalin-1 interacting human cell membrane receptor using phage displayUpdate on the molecular genetics of retinitis pigmentosaNonvisual light responses in the Rpe65 knockout mouse: rod loss restores sensitivity to the melanopsin system.RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell modelAge-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trialRetinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerizationRpe65 is the retinoid isomerase in bovine retinal pigment epithelium
P2860
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P2860
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
@en
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
@nl
type
label
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
@en
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
@nl
prefLabel
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
@en
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
@nl
P2093
P356
P1433
P1476
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle
@en
P2093
Hamasaki D
P2888
P304
P356
10.1038/3813
P407
P577
1998-12-01T00:00:00Z