Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.
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The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymeraseTRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymeraseThe Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid ArthritisPleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammationPARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetesIslet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitusDepletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in miceSearching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cellsPoly(ADP-ribosyl)ation reactions in the regulation of nuclear functionsMR angiography, MR imaging and proton MR spectroscopy in-vivo assessment of skeletal muscle ischemia in diabetic rats.Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ationPhotodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells.Poly(ADP-ribose) polymerase in the cellular response to DNA damage, apoptosis, and diseaseThe secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced nonapoptotic cell deathPoly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia.Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases.Lessons from the NZM2410 model and related strains.Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient miceAntihyperglycemic potentials of a threatened plant, Helonias dioica: antioxidative stress responses and the signaling cascade.Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference.PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells.Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease.Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integrationPartial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice.Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation.Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia.Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent diabetes mellitus?Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death.CXC chemokine ligand 12 protects pancreatic β-cells from necrosis through Akt kinase-mediated modulation of poly(ADP-ribose) polymerase-1 activity.WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasismPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus.The emerging role of autophagy in the pathophysiology of diabetes mellitus.
P2860
Q22010521-A7738B53-57E0-4508-AF8D-19A8F25BBBF5Q24671634-0BAF6F87-B327-4A06-96B7-1D5DCBCFEBD8Q26785513-FA978924-449B-4D98-8BA3-C2A9119F0F55Q26858894-273E8BE9-DF05-44C0-9DD2-834F8D5D86A2Q27312275-E5E49222-7128-4706-AF09-6973139E7221Q28115289-9CD8BE17-3F25-43FA-AAE3-14E907195123Q28343931-ECEC94B2-27CA-43CB-B3D1-0B475CB6B9C7Q28363666-D1510E0A-31DA-4D46-AA0D-B271DBE0500EQ28508144-F1322F8D-7109-41A6-8C26-6A4D0249770AQ28536983-2BFF0271-245F-46D7-AB16-0C94F8F4FE12Q29617672-020FF1EF-29BB-4EBC-83F6-69FED11270B8Q30571676-04284950-5505-45A7-890D-F603977A5236Q30640821-0B5994C2-BF75-47D5-990F-593C8C2F2D6CQ32182177-FBAB1FD0-E458-4652-8D93-F105B6AC285DQ33594926-DBA2F2FB-B05E-44CA-B473-37FE4343BC2AQ33779682-D06B4E3D-01E9-4876-AC72-DF8C57B3208FQ33845289-5E416FD3-9BD2-493D-876E-646675051B32Q34017468-E4B91410-8A67-4B5D-A557-9EDE65A9458EQ34042309-7BD74524-A91A-469B-B519-890EE82F7D6CQ34042969-736B3E70-9EC9-421E-A798-513EFFFF63B9Q34051998-68C9BECA-80AF-43C0-A269-0118C40762FEQ34080033-3EF8E56D-1EBC-4CE2-AFA7-4997B9294D98Q34101111-BCE93630-0BE1-48FD-B5FE-2E9A71792D26Q34223502-4456C608-B1D9-4AEC-9CF1-E22C232BE2A2Q34421470-92A96FD8-451E-4FFC-A76D-98C737DA5880Q34441033-546B3C46-1FBA-47AC-81FB-B617E07B3A58Q34570024-91BF91FA-8693-40E5-8B7C-0160A07C2F36Q34730830-2B7C4FEB-33F9-48D9-99A2-48627C7B22F9Q34896412-6B266DDD-52DB-443C-8ECA-894598943CD4Q34971545-06A05328-38A7-4518-A344-F85E7DEB3461Q35005601-875BDBC2-C0A3-480B-85C8-A56608FBC8B3Q35044253-C407F490-E1ED-4FAA-B60B-3F080E829C72Q35048713-5045FD92-B94C-4078-B420-FCBBCA567AF5Q35061709-9C19A8D1-78BF-4BF2-9ADD-003807F2603DQ35082036-5C67E7BA-8A28-466C-99B0-DC85B708BC00Q35200250-AA97CCDD-72AC-46E8-8EC6-6FA66658D77FQ35561063-D2BB3FE8-1E3C-43B9-8B14-DABC369C29FDQ35654707-DEF77D55-EC9F-4187-BC4C-487E43421325Q35903412-C1D77D2E-5BA7-4FE5-8C43-62E32735797AQ35985421-9B09115A-EB07-4BC7-A1E9-FF539B8E4813
P2860
Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Mice lacking the poly
@nl
Mice lacking the poly(ADP-ribo ...... pment induced by streptozocin.
@en
type
label
Mice lacking the poly
@nl
Mice lacking the poly(ADP-ribo ...... pment induced by streptozocin.
@en
prefLabel
Mice lacking the poly
@nl
Mice lacking the poly(ADP-ribo ...... pment induced by streptozocin.
@en
P2093
P356
P1433
P1476
Mice lacking the poly(ADP-ribo ...... pment induced by streptozocin.
@en
P2093
P2888
P304
P356
10.1038/6535
P407
P577
1999-03-01T00:00:00Z