A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
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Adenosine-to-inosine RNA editing and human diseaseLinking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle developmentTDP-43 suppresses tau expression via promoting its mRNA instability.Molecular network analysis suggests a logical hypothesis for the pathological role of c9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia.Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injuryThe AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.Immunolocalization of TAR DNA-binding protein of 43 kDa (TDP-43) in mouse seminiferous epithelium.Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic miceDivergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALSCalcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis.Current developments in gene therapy for amyotrophic lateral sclerosis.The Good and the Bad of Glutamate Receptor RNA Editing.Calpain research for drug discovery: challenges and potential.Altered Intracellular Milieu of ADAR2-Deficient Motor Neurons in Amyotrophic Lateral SclerosisCalpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons.The Neurotoxic TAU45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects.RETRACTED: Gene expression analysis in response to osmotic stimuli in the intervertebral disc with DNA microarray.Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons.CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties.Different aggregation states of a nuclear localization signal-tagged 25-kDa C-terminal fragment of TAR RNA/DNA-binding protein 43 kDa.TDP-43 modification in the hSOD1(G93A) amyotrophic lateral sclerosis mouse model.Towards a TDP-43-Based Biomarker for ALS and FTLD.Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain.Pathomechanisms of TDP-43 in neurodegeneration.
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P2860
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
A role for calpain-dependent c ...... c lateral sclerosis pathology.
@en
A role for calpain-dependent c ...... c lateral sclerosis pathology.
@nl
type
label
A role for calpain-dependent c ...... c lateral sclerosis pathology.
@en
A role for calpain-dependent c ...... c lateral sclerosis pathology.
@nl
prefLabel
A role for calpain-dependent c ...... c lateral sclerosis pathology.
@en
A role for calpain-dependent c ...... c lateral sclerosis pathology.
@nl
P2093
P2860
P356
P1476
A role for calpain-dependent c ...... c lateral sclerosis pathology.
@en
P2093
Jiro Takano
Kosuke Hachiga
Nobuhisa Iwata
Sayaka Teramoto
Takaomi C Saido
Takenari Yamashita
Takuto Hideyama
P2860
P2888
P356
10.1038/NCOMMS2303
P407
P577
2012-01-01T00:00:00Z