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Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromoleculesStructural features of human histone acetyltransferase p300 and its complex with p53An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityAurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppressionCrosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA bindingTrim24 targets endogenous p53 for degradationExpression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine modelQuaternary structures of tumor suppressor p53 and a specific p53 DNA complexImpact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 Å resolutionTargeted rescue of a destabilized mutant of p53 by an in silico screened drugStructural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repairCrystal structure of a p53 core tetramer bound to DNAStructural evolution of p53, p63, and p73: Implication for heterotetramer formationCrystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled TetramerDiversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairsStructure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T CellsStructures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elementsAcetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationSpacing between core recognition motifs determines relative orientation of AraR monomers on bipartite operatorsPliable DNA Conformation of Response Elements Bound to Transcription Factor p63Structure of p73 DNA-binding domain tetramer modulates p73 transactivationStructure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertionStructural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactionsTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeThe DNA-binding domain mediates both nuclear and cytosolic functions of p53Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancerp53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemInteraction of OKL38 and p53 in regulating mitochondrial structure and functionDifferential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidencesModulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutationsSignificant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug TreatmentTP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephantsStructure of full-length p53 tumor suppressor probed by chemical cross-linking and mass spectrometry.Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions.An Integrated Mass Spectrometry Based Approach to Probe the Structure of the Full-Length Wild-Type Tetrameric p53 Tumor Suppressor.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.Estrogen receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences.Two p53 tetramers bind one consensus DNA response elementStability of the core domain of p53: insights from computer simulations.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Structural basis of DNA recognition by p53 tetramers.
@en
Structural basis of DNA recognition by p53 tetramers.
@nl
type
label
Structural basis of DNA recognition by p53 tetramers.
@en
Structural basis of DNA recognition by p53 tetramers.
@nl
prefLabel
Structural basis of DNA recognition by p53 tetramers.
@en
Structural basis of DNA recognition by p53 tetramers.
@nl
P2093
P1433
P1476
Structural basis of DNA recognition by p53 tetramers.
@en
P2093
Dov Rabinovich
Lihi Shaulov
Malka Kitayner
Naama Kessler
Zippora Shakked
P304
P356
10.1016/J.MOLCEL.2006.05.015
P577
2006-06-01T00:00:00Z