Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV.
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Contribution of the ATP binding site of ParE to susceptibility to novobiocin and quinolones in Streptococcus pneumoniaeAlterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones.Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.How antibiotics kill bacteria: from targets to networksSynthesis, Characterization, and Antifungal Studies of Cr(III) Complex of Norfloxacin and Bipiridyl LigandGenetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America.Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplificationFluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.Quinolone-mediated bacterial death.Quinolones: action and resistance updated.Bacterial DNA replication enzymes as targets for antibacterial drug discovery.The DNA cleavage reaction of DNA gyrase. Comparison of stable ternary complexes formed with enoxacin and CcdB protein.A two-drug model for etoposide action against human topoisomerase IIalpha.Replicative helicases can translocate through abasic site-induced covalent topoisomerase IV-DNA complexes.Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases.Evaluation of complexes of DNA duplexes and novel benzoxazoles or benzimidazoles by electrospray ionization mass spectrometry.Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones.Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.The RuvAB branch migration complex can displace topoisomerase IV.quinolone.DNA ternary complexes.Novel symmetric and asymmetric DNA scission determinants for Streptococcus pneumoniae topoisomerase IV and gyrase are clustered at the DNA breakage site.Topoisomerase IV catalysis and the mechanism of quinolone action.History of antibiotics: from fluoroquinolones to daptomycin (Part 2).DNA Topoisomerases as Targets for Antibacterial Agents.Metal complex of the first-generation quinolone antimicrobial drug nalidixic acid: structure and its biological evaluation.Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.Mutational analysis of Escherichia coli topoisomerase IV. III. Identification of a region of parE involved in covalent catalysis.The DNA Gyrase-Quinolone Complex
P2860
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P2860
Mechanism of quinolone action. A drug-induced structural perturbation of the DNA precedes strand cleavage by topoisomerase IV.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Mechanism of quinolone action. ...... cleavage by topoisomerase IV.
@en
Mechanism of quinolone action. ...... cleavage by topoisomerase IV.
@nl
type
label
Mechanism of quinolone action. ...... cleavage by topoisomerase IV.
@en
Mechanism of quinolone action. ...... cleavage by topoisomerase IV.
@nl
prefLabel
Mechanism of quinolone action. ...... cleavage by topoisomerase IV.
@en
Mechanism of quinolone action. ...... cleavage by topoisomerase IV.
@nl
P2860
P356
P1476
Mechanism of quinolone action. ...... cleavage by topoisomerase IV.
@en
P2093
P2860
P304
P356
10.1074/JBC.272.14.9401
P407
P577
1997-04-01T00:00:00Z