about
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentS6K1 plays a critical role in early adipocyte differentiationS6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathwayMechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growthHypothalamic mTOR signaling regulates food intakeRapamycin causes regression of astrocytomas in tuberous sclerosis complexMetabolic control by S6 kinases depends on dietary lipidsAbsence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityIdentifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data.The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in DrosophilaMuscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production.Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistanceThe amino acid sensitive TOR pathway from yeast to mammals.mTOR, cancer and transplantation.Research and innovation in the development of everolimus for oncology.A matter of energy stress: p38β meets mTORC1Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity.Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.Phytohormones participate in an S6 kinase signal transduction pathway in Arabidopsis.The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.Bending the path to TOR.
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P50
description
researcher
@en
հետազոտող
@hy
name
George Thomas
@ast
George Thomas
@en
George Thomas
@es
George Thomas
@nl
George Thomas
@sl
type
label
George Thomas
@ast
George Thomas
@en
George Thomas
@es
George Thomas
@nl
George Thomas
@sl
prefLabel
George Thomas
@ast
George Thomas
@en
George Thomas
@es
George Thomas
@nl
George Thomas
@sl
P106
P21
P31
P496
0000-0003-3518-8149