Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. - Wikidata - wikimedia - TriplyDB

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

http://www.wikidata.org/entity/Q39707409

about

Risk of cancer in diabetes: the effect of metformin Metformin in reproductive health, pregnancy and gynaecological cancer: established and emerging indications Repurposing metformin: an old drug with new tricks in its binding pockets TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 The AMPK signalling pathway coordinates cell growth, autophagy and metabolism The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance Diabetes mellitus and metformin in hepatocellular carcinoma Targeting mTOR in Pancreatic Ductal Adenocarcinoma Management of Hidradenitis Suppurativa in Patients with Metabolic Comorbidities Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR The crucial impact of lysosomes in aging and longevity Repurposing metformin for cancer treatment: current clinical studies Energy disruptors: rising stars in anticancer therapy?Obesity and cancer, a case for insulin signaling New mechanisms of metformin action: Focusing on mitochondria and the gut Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends Leucine and mTORC1: a complex relationship Amino acids and mTORC1: from lysosomes to disease Cellular and molecular mechanisms of metformin: an overview Nutrient regulation of the mTOR complex 1 signaling pathway Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives Modeling dietary influences on offspring metabolic programming in Drosophila melanogaster Anti-tumor activity of metformin: from metabolic and epigenetic perspectives Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies Sestrins inhibit mTORC1 kinase activation through the GATOR complex Rapalogs and mTOR inhibitors as anti-aging therapeutics Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1 Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 Leucine signaling in the pathogenesis of type 2 diabetes and obesity Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress Cancer biology in diabetes.

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P2860

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

http://www.wikidata.org/entity/Q39707409

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-sg

2010年學術文章

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2010年學術文章

@zh

2010年學術文章

@zh-hant

name

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

@en

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

@nl

type

label

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

@en

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

@nl

prefLabel

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

@en

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

@nl

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P356

J.CMET.2010.03.014

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Cell Metabolism

P1476

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

@en

P2093

Adem Kalender

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Anand Selvaraj

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André Marette

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John J Schlager

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Nabeel Bardeesy

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Patrick Dennis

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Pawan Gulati

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Sara C Kozma

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So Young Kim

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Sophie Brûlé

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P2860

Role of AMP-activated protein kinase in mechanism of metformin action

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

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390-401

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scholarly article

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10.1016/J.CMET.2010.03.014

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5

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11

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Bruce Ernest Kemp

Nabeel Bardeesy

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2010-05-01T00:00:00Z

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44575026

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20444419

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3081779

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