Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.
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Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complexSolvent dependency of the UV-Vis spectrum of indenoisoquinolines: role of keto-oxygens as polarity interaction probesReplacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantRecovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation.Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein-DNA binding siteA kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity.Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin.A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism.Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.Sequence selectivity of the cleavage sites induced by topoisomerase I inhibitors: a molecular dynamics study.Distribution bias and biochemical characterization of TOP1MT single nucleotide variants.Subnuclear Localization of Human Topoisomerase I.Substitutions in Spodoptera exigua topoisomerase I modulate its relaxation activity and camptothecin sensitivity.
P2860
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P2860
Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 18 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Evidence of the crucial role o ...... ation of the Lys681Ala mutant.
@en
Evidence of the crucial role o ...... ation of the Lys681Ala mutant.
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type
label
Evidence of the crucial role o ...... ation of the Lys681Ala mutant.
@en
Evidence of the crucial role o ...... ation of the Lys681Ala mutant.
@nl
prefLabel
Evidence of the crucial role o ...... ation of the Lys681Ala mutant.
@en
Evidence of the crucial role o ...... ation of the Lys681Ala mutant.
@nl
P2093
P2860
P50
P356
P1476
Evidence of the crucial role o ...... zation of the Lys681Ala mutant
@en
P2093
Alessia Muzi
Giordano Mancini
Ilda D'Annessa
Paola Fiorani
P2860
P304
P356
10.1093/NAR/GKP669
P407
P577
2009-09-18T00:00:00Z