Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases
about
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation siteMirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaPhosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinasesMirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblastsThe zebrafish dyrk1b gene is important for endoderm formationOverexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosomeIdentification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1AThe protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation siteMirk kinase inhibition targets ovarian cancer ascites.Developmental transcriptome analysis of human erythropoiesis.The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells.Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.New targets to treat obesity and the metabolic syndrome.Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cellsFission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division.Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties.DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy.Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control.MuvB: A Key to Cell Cycle Control in Ovarian Cancer.
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P2860
Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases
description
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
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artículu científicu espublizáu en 1999
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im Januar 1999 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 1999/01/19)
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vědecký článek publikovaný v roce 1999
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wetenschappelijk artikel (gepubliceerd op 1999/01/19)
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наукова стаття, опублікована в січні 1999
@uk
مقالة علمية (نشرت في 19-1-1999)
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name
Cloning and characterization o ...... DYRK family of protein kinases
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Cloning and characterization o ...... DYRK family of protein kinases
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Cloning and characterization o ...... DYRK family of protein kinases
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type
label
Cloning and characterization o ...... DYRK family of protein kinases
@ast
Cloning and characterization o ...... DYRK family of protein kinases
@en
Cloning and characterization o ...... DYRK family of protein kinases
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prefLabel
Cloning and characterization o ...... DYRK family of protein kinases
@ast
Cloning and characterization o ...... DYRK family of protein kinases
@en
Cloning and characterization o ...... DYRK family of protein kinases
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P50
P356
P1476
Cloning and characterization o ...... DYRK family of protein kinases
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P304
P356
10.1006/BBRC.1998.9967
P407
P577
1999-01-01T00:00:00Z