DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
about
Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppressionThe origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expressionGerminal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regionsHypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomasRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsDNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseVariable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombinationLinking class-switch recombination with somatic hypermutation.AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Mechanisms of chromosomal translocations in B cell lymphomas.Immunoglobulin variable-region gene usage in systemic autoimmune diseases.Targeting of somatic hypermutation.Emerging links between hypermutation of antibody genes and DNA polymerases.AID and mismatch repair in antibody diversification.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Mechanisms of B-cell lymphoma pathogenesis.The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis.Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.Molecular pathways in follicular lymphoma.Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription.BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells.Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks.AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line.Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.Palindromic but not G-rich sequences are targets of class switch recombination.Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.Immunology. Antibody alterations.Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.Monocytoid B cells: an enigmatic B cell subset showing evidence of extrafollicular immunoglobulin gene somatic hypermutation.Distinct Patterns of Colocalization of the CCND1 and CMYC Genes With Their Potential Translocation Partner IGH at Successive Stages of B-Cell Differentiation.Hypermutation: give us a break
P2860
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P2860
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
description
article
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 2000
@uk
name
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
@en
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
@nl
type
label
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
@en
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
@nl
prefLabel
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
@en
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
@nl
P2093
P1433
P1476
DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation
@en
P2093
Corinne Démollière
Fraser McBlane
Linda Bross
Yosho Fukita
P304
P356
10.1016/S1074-7613(00)00059-5
P407
P577
2000-11-01T00:00:00Z