about
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeresERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomesXPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shorteningMRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length controlHuman XPF controls TRF2 and telomere length maintenance through distinctive mechanismsATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresCleavage-dependent ligation by the FLP recombinase. Characterization of a mutant FLP protein with an alteration in a catalytic amino acidCockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance.Cdk-dependent phosphorylation regulates TRF1 recruitment to PML bodies and promotes C-circle production in ALT cells.Methylated TRF2 associates with the nuclear matrix and serves as a potential biomarker for cellular senescence.Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation.ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance.Arginine methylation regulates telomere length and stability.Cyclin B-dependent kinase 1 regulates human TRF1 to modulate the resolution of sister telomeres.TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies.ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.Efficient UV repair requires disengagement of the CSB winged helix domain from the CSB ATPase domainBiphasic recruitment of TRF2 to DNA damage sites promotes non-sister chromatid homologous recombination repairCSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resectionCSB cooperates with SMARCAL1 to maintain telomere stability in ALT cells
P50
Q22254585-03A3119E-86E4-46E6-B471-427ED1E185ADQ24302611-A93D408D-0873-47AE-AA08-A063CCD6E1BDQ24307902-A755F3F4-6B96-43DC-860D-4FB3970C72A2Q28115619-B75BAFEF-E189-43D7-9EF3-A6F102C053E1Q28116315-2AFF9457-E2E3-47CD-95E7-988EDE745F00Q28117859-87E2A332-03E4-4359-AAFB-0128BE4A64A9Q28289373-2A01514B-E765-4B59-8F78-AC2DEFFA3FDEQ34469204-BDEBD021-A4CE-4286-B8E8-DEA3D2C9C151Q38013495-7837D1AA-852C-4FDC-894F-DF03C648A3A4Q38770512-21826624-5088-4B5F-B4EA-B1BF93C3034FQ39005455-6083550B-DB89-4C2E-A27F-1B85AD892A25Q39101297-31EF4760-526B-40E6-A3C7-4379A19067BCQ39408275-E5E21F33-EB4D-4751-8DCC-076F1794309FQ39825872-FD2AFAC3-38D8-4B85-B915-5F834D7E8336Q41894182-DA2E24FC-2B07-423F-9300-D17F737289B5Q42107594-923D2A13-C4B5-46A1-9A48-C37669CD21B0Q47144713-700D3523-44DE-4220-A585-8DA9E1A8FC71Q57753477-9DC528B7-4C1B-4932-8407-1FCF178EF4E3Q58596785-36A63428-9ABB-45C1-B32D-25C1FFC5CDEDQ90006804-22A613B1-DC19-447E-BD09-D5A6F6370051Q92888312-D7DBF102-08A4-4A80-9F17-B830CF154971
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Xu-Dong Zhu
@ast
Xu-Dong Zhu
@en
Xu-Dong Zhu
@es
Xu-Dong Zhu
@nl
type
label
Xu-Dong Zhu
@ast
Xu-Dong Zhu
@en
Xu-Dong Zhu
@es
Xu-Dong Zhu
@nl
prefLabel
Xu-Dong Zhu
@ast
Xu-Dong Zhu
@en
Xu-Dong Zhu
@es
Xu-Dong Zhu
@nl
P106
P31
P496
0000-0003-1859-3134