Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetesA Review on Platensimycin: A Selective FabF InhibitorNext-generation antimicrobials: from chemical biology to first-in-class drugsBacterial lipids: metabolism and membrane homeostasisThe Role of Medical Structural Genomics in Discovering New Drugs for Infectious DiseasesIdentification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl ReductaseMode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI InhibitorStructural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteriaStructural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureusRational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product ComplexStaphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo EssentialityStructural and Enzymatic Analyses Reveal the Binding Mode of a Novel Series of Francisella tularensis Enoyl Reductase (FabI) InhibitorsRational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase InhibitorStructure of shikimate kinase, an in vivo essential metabolic enzyme in the nosocomial pathogen Acinetobacter baumannii, in complex with shikimateResistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) AntibioticsFapR: From Control of Membrane Lipid Homeostasis to a Biotechnological ToolTriclosan promotes Staphylococcus aureus nasal colonizationFatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infectionPseudomonas aeruginosa directly shunts β-oxidation degradation intermediates into de novo fatty acid biosynthesisFatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthasesDeletion of the β-acetoacetyl synthase FabY in Pseudomonas aeruginosa induces hypoacylation of lipopolysaccharide and increases antimicrobial susceptibilityAntibiotics May Trigger Mitochondrial Dysfunction Inducing Psychiatric DisordersAntibiotics for emerging pathogensThe transcriptome of the nosocomial pathogen Enterococcus faecalis V583 reveals adaptive responses to growth in blood.Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assaysBlueprint for antimicrobial hit discovery targeting metabolic networksComparative genomic analysis of pathogenic and probiotic Enterococcus faecalis isolates, and their transcriptional responses to growth in human urinePostgenomic strategies in antibacterial drug discovery.Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosisChallenges of antibacterial discoveryProbing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureusCarbonic anhydrase is essential for Streptococcus pneumoniae growth in environmental ambient air.Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matchingNovel anti-infective compounds from marine bacteria.Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesisBranched-chain fatty acids promote Listeria monocytogenes intracellular infection and virulence.Extensive in vivo resilience of persistent SalmonellaMechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model.
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Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в березні 2009
@uk
name
Type II fatty acid synthesis i ...... et for Gram-positive pathogens
@en
Type II fatty acid synthesis i ...... et for Gram-positive pathogens
@nl
type
label
Type II fatty acid synthesis i ...... et for Gram-positive pathogens
@en
Type II fatty acid synthesis i ...... et for Gram-positive pathogens
@nl
prefLabel
Type II fatty acid synthesis i ...... et for Gram-positive pathogens
@en
Type II fatty acid synthesis i ...... et for Gram-positive pathogens
@nl
P50
P356
P1433
P1476
Type II fatty acid synthesis i ...... et for Gram-positive pathogens
@en
P2093
Gilles Lamberet
Sophie Brinster
P2860
P2888
P356
10.1038/NATURE07772
P407
P577
2009-03-01T00:00:00Z
P6179
1022806704