Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion
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The emerging role of histone lysine demethylases in prostate cancerHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionQuantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysisHistone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis.The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells.Exploiting Epigenetic Alterations in Prostate Cancer.Epigenetic regulation of epithelial-mesenchymal transitionPHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/β-catenin signaling pathway.Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.Small-molecular modulators of cancer-associated epigenetic mechanisms.Oncogenic features of PHF8 histone demethylase in esophageal squamous cell carcinoma.Inference of transcriptional regulation in cancers.The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration.Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic ReplicationEpigenetically Modified Bone Marrow Stromal Cells in Silk Scaffolds Promote Craniofacial Bone Repair and Wound Healing.KDM4A, KDM4B and KDM4C in non-small cell lung cancer.A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In VitroCharacterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A.Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686.Expanding the Diversity of Imaging-Based RNAi Screen Applications Using Cell Spot Microarrays.The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20Androgen receptor activation by polychlorinated biphenyls: epigenetic effects mediated by the histone demethylase Jarid1b.The HIF/PHF8/AR axis promotes prostate cancer progression.c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer.Roles of histone methyl-modifying enzymes in development and progression of cancer.Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis.The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression.Elevated expression of histone demethylase PHF8 associates with adverse prognosis in patients of laryngeal and hypopharyngeal squamous cell carcinoma.Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing.SMYD3 as an oncogenic driver in prostate cancer by stimulation of androgen receptor transcription.The histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b.Plant Homeo Domain Finger Protein 8 Regulates Mesodermal and Cardiac Differentiation of Embryonic Stem Cells Through Mediating the Histone Demethylation of pmaip1.Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3.JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress.Epigenetic Regulation in Prostate Cancer Progression.PHF8 upregulation contributes to autophagic degradation of E-cadherin, epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma
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Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion
description
im November 2011 veröffentlichter wissenschaftlicher Artikel
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scientific article published on 28 November 2011
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wetenschappelijk artikel
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наукова стаття, опублікована в листопаді 2011
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name
Systematic knockdown of epigen ...... ration, migration and invasion
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Systematic knockdown of epigen ...... ration, migration and invasion
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type
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Systematic knockdown of epigen ...... ration, migration and invasion
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Systematic knockdown of epigen ...... ration, migration and invasion
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prefLabel
Systematic knockdown of epigen ...... ration, migration and invasion
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Systematic knockdown of epigen ...... ration, migration and invasion
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P2093
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Systematic knockdown of epigen ...... ration, migration and invasion
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E Kaivanto
J Virtanen
J-P Mpindi
M Björkman
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P2888
P304
P356
10.1038/ONC.2011.512
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P50
P577
2011-11-28T00:00:00Z