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Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammationGenetics ignite focus on microglial inflammation in Alzheimer's diseaseTREM2 in CNS homeostasis and neurodegenerative diseaseThe triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesisTriggering receptor expressed on myeloid cells receptor family modulators: a patent reviewFunctional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunityExpression and functional role of MDL-1 (CLEC5A) in mouse myeloid lineage cellsNeuroinflammation - using big data to inform clinical practice.Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanismsBone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency.TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice.Temporal-logic analysis of microglial phenotypic conversion with exposure to amyloid-β.The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells.Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.TREM2 protects against cerebral ischemia/reperfusion injuryTREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.Coding variants in TREM2 increase risk for Alzheimer's diseaseMicroglia: unique and common features with other tissue macrophages.Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's diseaseAttenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke.Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?Proteomic analysis of lymphoblastoid cells from Nasu-Hakola patients: a step forward in our understanding of this neurodegenerative disorder.Differential modulation of TREM2 protein during postnatal brain development in mice.Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice.The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.Global analyses of Chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes.TREM-2 promotes macrophage survival and lung disease after respiratory viral infectionThe expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.Immune aging, dysmetabolism, and inflammation in neurological diseases.A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis.DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic Patients with Carotid Stenosis.Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental MelioidosisTLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release.TREM2 regulates microglial cell activation in response to demyelination in vivo.Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype
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description
im September 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 September 2006
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2006
@uk
name
Cutting Edge: TREM-2 Attenuates Macrophage Activation
@en
Cutting Edge: TREM-2 Attenuates Macrophage Activation
@nl
type
label
Cutting Edge: TREM-2 Attenuates Macrophage Activation
@en
Cutting Edge: TREM-2 Attenuates Macrophage Activation
@nl
prefLabel
Cutting Edge: TREM-2 Attenuates Macrophage Activation
@en
Cutting Edge: TREM-2 Attenuates Macrophage Activation
@nl
P2093
P1476
Cutting edge: TREM-2 attenuates macrophage activation
@en
P2093
Isaiah R Turnbull
Laura Piccio
Marco Colonna
Maristela Hernandez
Mark Miller
Susan Gilfillan
Taiki Aoshi
P304
P356
10.4049/JIMMUNOL.177.6.3520
P407
P50
P577
2006-09-01T00:00:00Z