Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition
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Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factorThe yeast oxysterol binding protein Kes1 maintains sphingolipid levelsInvolvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cellsComparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitorPhospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesisRegulation of phosphoinositide levels by the phospholipid transfer protein Sec14p controls Cdc42p/p21-activated kinase-mediated cell cycle progression at cytokinesisA Phase 1, Multi-Center, Open-Label, Dose-Escalation Study of 131I-CLR1404 in Subjects with Relapsed or Refractory Advanced Solid Malignancies.Vitamin E prevents lipid raft modifications induced by an anti-cancer lysophospholipid and abolishes a Yap1-mediated stress response in yeast.The yeast sphingolipid signaling landscape.The SK3/K(Ca)2.3 potassium channel is a new cellular target for edelfosine.Localization of lipid raft proteins to the plasma membrane is a major function of the phospholipid transfer protein Sec14.Human TMEM30a promotes uptake of antitumor and bioactive choline phospholipids into mammalian cellsInvolvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeastPivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid.Minerval induces apoptosis in Jurkat and other cancer cells.Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol.Evaluation of extraction protocols for simultaneous polar and non-polar yeast metabolite analysis using multivariate projection methodsLipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.Lipids and cell death in yeast.Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.Mitochondrial-derived ROS in edelfosine-induced apoptosis in yeasts and tumor cells.Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast.Identification of new surfaces of cofilin that link mitochondrial function to the control of multi-drug resistance.Lipid raft involvement in yeast cell growth and death.Membrane rafts are involved in intracellular miconazole accumulation in yeast cells.Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation.Effect of anti-tumor ether lipids on ordered domains in model membranesDifferential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor CellsA Chemogenomic Screen inSaccharomyces cerevisiaeUncovers a Primary Role for the Mitochondria in Farnesol Toxicity and Its Regulation by the Pkc1 Pathway
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Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im September 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
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wetenschappelijk artikel
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наукова стаття, опублікована у вересні 2005
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name
Cytotoxicity of an Anti-cancer ...... tion of Lipid Raft Composition
@en
Cytotoxicity of an Anti-cancer ...... tion of Lipid Raft Composition
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type
label
Cytotoxicity of an Anti-cancer ...... tion of Lipid Raft Composition
@en
Cytotoxicity of an Anti-cancer ...... tion of Lipid Raft Composition
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prefLabel
Cytotoxicity of an Anti-cancer ...... tion of Lipid Raft Composition
@en
Cytotoxicity of an Anti-cancer ...... tion of Lipid Raft Composition
@nl
P2093
P2860
P356
P1476
Cytotoxicity of an anti-cancer ...... tion of lipid raft composition
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Christopher R McMaster
Faustino Mollinedo
Luis M Cacharro
Vanina Zaremberg
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P304
38047-38058
P356
10.1074/JBC.M502849200
P407
P577
2005-09-09T00:00:00Z