Differential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells
about
Exogenous ether lipids predominantly target mitochondriaInvolvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cellsIn vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasitesSynthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway.Lipid raft-targeted therapy in multiple myeloma.The SK3/K(Ca)2.3 potassium channel is a new cellular target for edelfosine.Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeastLipid rafts and caveolae in signaling by growth factor receptors.Lipid analogues as potential drugs for the regulation of mitochondrial cell death.PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.Caenorhabditis elegans as a platform to study the mechanism of action of synthetic antitumor lipidsMitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis.Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells.
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Differential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im März 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2006
@uk
name
Differential Targets and Subce ...... eukemicVersusSolid Tumor Cells
@en
Differential Targets and Subce ...... eukemicVersusSolid Tumor Cells
@nl
type
label
Differential Targets and Subce ...... eukemicVersusSolid Tumor Cells
@en
Differential Targets and Subce ...... eukemicVersusSolid Tumor Cells
@nl
prefLabel
Differential Targets and Subce ...... eukemicVersusSolid Tumor Cells
@en
Differential Targets and Subce ...... eukemicVersusSolid Tumor Cells
@nl
P2860
P356
P1476
Differential targets and subce ...... kemic versus solid tumor cells
@en
P2093
Faustino Mollinedo
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P304
14833-14840
P356
10.1074/JBC.M511251200
P407
P577
2006-03-15T00:00:00Z