about
Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).Functional implications of hippocampal adult neurogenesis in intellectual disabilities.Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex.Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice.Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes.Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans.Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-).Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity.Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons.
P50
Q33354112-C25DE751-BDC9-4B24-B5E5-E6D4B6EA0D3AQ38100616-321CC6EE-23F7-45E1-86BD-F283A4BA8FD0Q39875864-284774B0-C9F5-4F5E-9E72-B7348C8810FAQ42144929-11F300FF-1F6D-4043-93F2-73DC40704634Q43555844-DE648C45-73A1-4FE6-8A80-BF5D29ECC9C0Q44545341-7C3EB35F-6566-4A0C-A134-8BD1082FAF14Q46157547-0E11317E-031D-47AB-8D30-A0576E0ED417Q48351743-6EAEEA08-58CE-4464-8B7E-801AE3826D52Q48529835-EC080A09-3EF8-4E11-8E07-F4C0B6C5DB3FQ48730272-1E29BF0E-3128-43F2-A24C-6B27B044CB84
P50
description
onderzoeker
@nl
researcher ORCID ID = 0000-0002-0836-6491
@en
name
Maria Martinez de Lagran
@ast
Maria Martinez de Lagran
@en
Maria Martinez de Lagran
@es
Maria Martinez de Lagran
@nl
type
label
Maria Martinez de Lagran
@ast
Maria Martinez de Lagran
@en
Maria Martinez de Lagran
@es
Maria Martinez de Lagran
@nl
prefLabel
Maria Martinez de Lagran
@ast
Maria Martinez de Lagran
@en
Maria Martinez de Lagran
@es
Maria Martinez de Lagran
@nl
P106
P1153
6505962601
P21
P31
P496
0000-0002-0836-6491