Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
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The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2Raf family kinases: old dogs have learned new tricksMAPK signaling in equations and embryosThe DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transportERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?RASopathies: unraveling mechanisms with animal modelsHow do cilia organize signalling cascades?Novel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms.Structural basis for reversible photoswitching in DronpaAllosteric modulation of Ras positions Q61 for a direct role in catalysisThe pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2.The N-terminal domain of ERK1 accounts for the functional differences with ERK2Investigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysisNoise propagation in two-step series MAPK cascadeExact hybrid particle/population simulation of rule-based models of biochemical systemsEnzyme Sequestration as a Tuning Point in Controlling Response Dynamics of Signalling NetworksModeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling PathwayAn essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cellsTailored parameter optimization methods for ordinary differential equation models with steady-state constraintsNetwork Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.Light-activated kinases enable temporal dissection of signaling networks in living cells.Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states.ODE constrained mixture modelling: a method for unraveling subpopulation structures and dynamicsA quantitative image cytometry technique for time series or population analyses of signaling networks.The Xenopus oocyte: a single-cell model for studying Ca2+ signaling.ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation.Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisionsAntibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold proteinEpidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysPhosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling.Single-cell western blotting.ERK as a model for systems biology of enzyme kinetics in cells.Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactionsCoulomb interactions between cytoplasmic electric fields and phosphorylated messenger proteins optimize information flow in cellsKnowledge-based design of a biosensor to quantify localized ERK activation in living cells.Elucidating the in vivo phosphorylation dynamics of the ERK MAP kinase using quantitative proteomics data and Bayesian model selection.
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Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
description
article publié dans la revue scientifique Journal of Biological Chemistry
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im Januar 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
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wetenschappelijk artikel
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наукова стаття, опублікована в січні 2006
@uk
name
Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
@en
Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
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type
label
Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
@en
Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
@nl
prefLabel
Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
@en
Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
@nl
P2093
P2860
P50
P356
P1476
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes
@en
P2093
Aki Fujioka
Eisuke Nishida
Kenta Terai
Shinya Kuroda
Takeshi Nakamura
P2860
P304
P356
10.1074/JBC.M509344200
P407
P577
2006-01-17T00:00:00Z