A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunityEssential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signalingChemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cellsGenome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipientsThe protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association.IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection.Regulatory T cells and Toll-like receptors: what is the missing link?Association pattern of interleukin-1 receptor-associated kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese population.Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.Interleukin-1 receptor-associated kinase-4 (IRAK4) promotes inflammatory osteolysis by activating osteoclasts and inhibiting formation of foreign body giant cells.Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies.Why are lipid rafts not observed in vivo?Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptorsIRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease.Defining the immune response to Ehrlichia species using murine models.The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammationTube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunityMembrane microdomains in immunity: glycosphingolipid-enriched domain-mediated innate immune responses.Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection.The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease.IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.Deficiency in IRAK4 activity attenuates manifestations of murine Lupus.Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infection.B cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model.Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth.The rLrp of Mycobacterium tuberculosis inhibits proinflammatory cytokine production and downregulates APC function in mouse macrophages via a TLR2-mediated PI3K/Akt pathway activation-dependent mechanism.Zinc Signals and Immunity.Hybrid lipids increase nanoscale fluctuation lifetimes in mixed membranes.
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A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
description
article publié dans la revue scientifique Science
@fr
im März 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Science
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2006
@uk
name
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
@en
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
@nl
type
label
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
@en
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
@nl
prefLabel
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
@en
A Critical Role for the Innate Immune Signaling Molecule IRAK-4 in T Cell Activation
@nl
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P50
P356
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P1476
A critical role for the innate immune signaling molecule IRAK-4 in T cell activation
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Alisha R Elford
Christine Mirtsos
Denis Bouchard
Douglas G Millar
Hiromitsu Hara
Jun-Ichiro Suzuki
Midori Unno
Nien-Jung Chen
Nobutaka Suzuki
Shinobu Suzuki
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P356
10.1126/SCIENCE.1124256
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P577
2006-03-01T00:00:00Z