Polo-like kinase-1 is a target of the DNA damage checkpoint
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Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyReactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolusNek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responsesSurvivin is required for a sustained spindle checkpoint arrest in response to lack of tensionInhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylationCheckpoint recovery in cells: how a molecular understanding can help in the fight against cancerDTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointCalcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cellsThe Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointM-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCPPolo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recoveryPolo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnoverPolo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbodyPolo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradationSurvivin mediates targeting of the chromosomal passenger complex to the centromere and midbodyCell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrityUncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeresThe forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centriolesTreatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.NaRole of Plk2 (Snk) in mouse development and cell proliferationMaintaining Genome Stability in Defiance of Mitotic DNA DamageContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisVolasertib for AML: clinical use and patient considerationPlk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell linesCdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.Inhibition of the mitotic exit network in response to damaged telomeres.DNA damage control: regulation and functions of checkpoint kinase 1Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathwaysThe G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulatorsPlk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathwayUbiquitin and SUMO systems in the regulation of mitotic checkpointsTumor suppressors and cell-cycle proteins in lung cancerPharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapyMammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20.Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner.DNA damage-induced cell death is enhanced by progression through mitosisChk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression
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Polo-like kinase-1 is a target of the DNA damage checkpoint
description
im September 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 September 2000
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2000
@uk
name
Polo-like kinase-1 is a target of the DNA damage checkpoint
@en
Polo-like kinase-1 is a target of the DNA damage checkpoint
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type
label
Polo-like kinase-1 is a target of the DNA damage checkpoint
@en
Polo-like kinase-1 is a target of the DNA damage checkpoint
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prefLabel
Polo-like kinase-1 is a target of the DNA damage checkpoint
@en
Polo-like kinase-1 is a target of the DNA damage checkpoint
@nl
P2093
P50
P356
P1433
P1476
Polo-like kinase-1 is a target of the DNA damage checkpoint
@en
P2093
P2888
P304
P356
10.1038/35023629
P577
2000-09-01T00:00:00Z