Lysine Scanning of Arg-Teixobactin: Deciphering the Role of Hydrophobic and Hydrophilic Residues
about
Targeting a cell wall biosynthesis hot spot.X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore.Alanine scan reveals modifiable residues in teixobactin.Chemistry and Biology of Teixobactin.Synthesis and biological evaluation of novel teixobactin analogues.Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l-allo-enduracididine with its isosteres.Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding.
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Lysine Scanning of Arg-Teixobactin: Deciphering the Role of Hydrophobic and Hydrophilic Residues
description
scientific article published on 19 December 2016
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wetenschappelijk artikel
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наукова стаття, опублікована в грудні 2016
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name
Lysine Scanning of Arg-Teixoba ...... hobic and Hydrophilic Residues
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Lysine Scanning of Arg-Teixoba ...... hobic and Hydrophilic Residues
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type
label
Lysine Scanning of Arg-Teixoba ...... hobic and Hydrophilic Residues
@en
Lysine Scanning of Arg-Teixoba ...... hobic and Hydrophilic Residues
@nl
prefLabel
Lysine Scanning of Arg-Teixoba ...... hobic and Hydrophilic Residues
@en
Lysine Scanning of Arg-Teixoba ...... hobic and Hydrophilic Residues
@nl
P2093
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P356
P1433
P1476
Lysine Scanning of Arg10-Teixo ...... hobic and Hydrophilic Residues
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P2093
Ayman El-Faham
Beatriz G de la Torre
Estelle J Ramchuran
Shimaa A H Abdel Monaim
Thavendran Govender
Yahya E Jad
P2860
P304
P356
10.1021/ACSOMEGA.6B00354
P407
P577
2016-12-19T00:00:00Z