S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
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Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucineInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondInterleukin-6 myokine signaling in skeletal muscle: a double-edged sword?Cellular and molecular mechanisms of muscle atrophymTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingRapalogs and mTOR inhibitors as anti-aging therapeuticsRibosomal protein S6 kinase 1 signaling regulates mammalian life spanIntracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1.TOR and ageing: a complex pathway for a complex process.Pharmacologic Means of Extending Lifespan.Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatinSynaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice.S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1.Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.Autophagy: regulation and role in disease.Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor.Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy.Rapamycin delays salivary gland atrophy following ductal ligation.Skeletal muscle protein metabolism in human heart failure.Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasomeA growing role for mTOR in promoting anabolic metabolism.The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli.Leucine‑induced anabolic‑catabolism: two sides of the same coin.mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cellsKey proteins and pathways that regulate lifespan.Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.mTOR/S6 kinase pathway contributes to astrocyte survival during ischemia.Activation of mTOR coincides with autophagy during ligation-induced atrophy in the rat submandibular gland.Differential effects of PDCD4 depletion on protein synthesis in myoblast and myotubesPositive feedback in cardioprotection: can more mechanism lead to translation?Gax suppresses chemerin/CMKLR1-induced preadipocyte biofunctions through the inhibition of Akt/mTOR and ERK signaling pathways.mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.Phosphodiesterase 5 inhibitors and cystic fibrosis: correcting chloride channel dysfunction.Preclinical evidence that sildenafil and vardenafil activate chloride transport in cystic fibrosis.Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration.Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine.Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock
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S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
description
im August 2007 veröffentlichter wissenschaftlicher Artikel
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2007
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name
S6 kinase inactivation impairs ...... regulation of protein turnover
@en
S6 kinase inactivation impairs ...... regulation of protein turnover
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type
label
S6 kinase inactivation impairs ...... regulation of protein turnover
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S6 kinase inactivation impairs ...... regulation of protein turnover
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prefLabel
S6 kinase inactivation impairs ...... regulation of protein turnover
@en
S6 kinase inactivation impairs ...... regulation of protein turnover
@nl
P2093
P1476
S6 kinase inactivation impairs ...... regulation of protein turnover
@en
P2093
Athanassia Sotiropoulos
Catherine Espeillac
Judith Klumperman
Marco Sandri
Mario Pende
Mickael Ohanna
Mila Roceri
Viola Oorschot
P304
P356
10.1152/AJPCELL.00499.2006
P577
2007-08-01T00:00:00Z