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The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expressionRecognition of multivalent histone states associated with heterochromatin by UHRF1 proteinICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cellsStructural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancerGenomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expressionTranscriptional regulation of the human topoisomerase IIalpha geneDown-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transitionThe retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycleAronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.Redox-sensitive up-regulation of eNOS by purple grape juice in endothelial cells: role of PI3-kinase/Akt, p38 MAPK, JNK, FoxO1 and FoxO3aDown-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer propertiesTandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation.The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides.UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis.Combinatorial DNA methylation codes at repetitive elements.CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4A in glioblastoma cells.Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis.Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancer.Peptidergic pathway in human skin and rat peritoneal mast cell activation.Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform.Potentiation by tumour necrosis factor-alpha of calcium signals induced by bradykinin and carbachol in human tracheal smooth muscle cells.UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity.The antiapoptotic protein ICBP90 is a target for protein kinase 2.ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells.Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery.1,25-Dihydroxyvitamin D3 induces splenocyte apoptosis and enhances BALB/c mice sensitivity to toxoplasmosis.Dynamics of Methylated Cytosine Flipping by UHRF1.Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy.Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.[The first stage of transmission of an epigenetic character followed by fluorescence].Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress.Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code.Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.
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P50
description
researcher ORCID ID = 0000-0002-3101-9279
@en
wetenschapper
@nl
name
Christian Bronner
@ast
Christian Bronner
@en
Christian Bronner
@es
Christian Bronner
@nl
type
label
Christian Bronner
@ast
Christian Bronner
@en
Christian Bronner
@es
Christian Bronner
@nl
prefLabel
Christian Bronner
@ast
Christian Bronner
@en
Christian Bronner
@es
Christian Bronner
@nl
P106
P21
P31
P496
0000-0002-3101-9279