Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
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p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosisAicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunityThe clearance of dying cells: table for twoClearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLEAnimal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside-a Comprehensive ReviewThe Role of the Transcriptional Regulation of Stromal Cells in Chronic InflammationNucleic acids in circulation: are they harmful to the host?Mechanisms linking excess adiposity and carcinogenesis promotionA conserved role for SNX9-family members in the regulation of phagosome maturation during engulfment of apoptotic cellsStructural Insights into Apoptotic DNA Degradation by CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegansPhagocytosis of apoptotic cells in homeostasisCytoplasmic DNA innate immune pathwaysApoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunityDNase 2 is the main DNA-degrading enzyme of the stratum corneumNucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responsesClearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis.A pathway for phagosome maturation during engulfment of apoptotic cellsCirculating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers.Thymic alterations in GM2 gangliosidoses model mice.Innate immune sensing of DNAImpaired clearance of apoptotic cells in chronic inflammatory diseases: therapeutic implicationsCloning and characterization of a novel Drosophila stress induced DNase.Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses.Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory diseaseCytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.Biogenesis and proteolytic processing of lysosomal DNase IISuppression of systemic autoimmunity by the innate immune adaptor STING.AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin.Innate Immune Signaling by, and Genetic Adjuvants for DNA VaccinationSpontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis.cGMP-AMP synthase paves the way to autoimmunityActivation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseasesNucleosides accelerate inflammatory osteolysis, acting as distinct innate immune activators.STING manifests self DNA-dependent inflammatory disease.AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunityDesigning DNA nanodevices for compatibility with the immune system of higher organismsIntracellular detection and immune signaling pathways of DNA vaccines.Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB × NZW) F1 mice.The STING pathway and regulation of innate immune signaling in response to DNA pathogens.
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Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в жовтні 2006
@uk
name
Chronic polyarthritis caused b ...... rom degradation in macrophages
@en
Chronic polyarthritis caused b ...... rom degradation in macrophages
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type
label
Chronic polyarthritis caused b ...... rom degradation in macrophages
@en
Chronic polyarthritis caused b ...... rom degradation in macrophages
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prefLabel
Chronic polyarthritis caused b ...... rom degradation in macrophages
@en
Chronic polyarthritis caused b ...... rom degradation in macrophages
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Chronic polyarthritis caused b ...... rom degradation in macrophages
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Hideki Yoshikawa
Keiko Miwa
Kohki Kawane
Mayumi Ohtani
Shigekazu Nagata
Takuji Kizawa
Yoshichika Yoshioka
Yoshiyuki Kanbara
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P304
P356
10.1038/NATURE05245
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P577
2006-10-01T00:00:00Z
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1023005162