The role of clonal selection and somatic mutation in autoimmunity
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Lack of allelic exclusion in B cell chronic lymphocytic leukemiaThe analysis of clonal expansions in normal and autoimmune B cell repertoiresSomatic mutagenesis in autoimmunityImmunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytesFcγRIIB and autoimmunity.Evidence for a bias toward intracellular antigens in the local humoral anti-tumor immune response of a colorectal cancer patient revealed by phage display.Analysis of Ig kappa light chain gene variable regions expressed in the rheumatoid synovial B cells.Recombinant human natural autoantibodies against GPIIb/IIIa inhibit binding of autoantibodies from patients with AITP.Anti-insulin antibodies and the natural autoimmune response in systemic lupus erythematosus.Human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection.Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies.Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and futureThe central and multiple roles of B cells in lupus pathogenesis.Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humansInducible resistance to Fas-mediated apoptosis in B cells.Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.Immunochemistry of DNA.From T to B and back again: positive feedback in systemic autoimmune disease.Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice.Toll-like receptors as potential therapeutic targets for multiple diseases.Malignant B cells and antigenic receptor: necessity or habit?Systematic analysis of sequences of anti-DNA antibodies--relevance to theories of origin and pathogenicity.The molecular biology of anti-DNA antibodies and their idiotopes.Genetic regulation of CD5+ B cells in autoimmune disease and in chronic lymphocytic leukemia.Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response.Mouse variable-region gene families: complexity, polymorphism and use in non-autoimmune responses.High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination.Development and selection of marginal zone B cells.Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3.Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus.Memory B lymphocytes migrate to bone marrow in humansOverlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus.Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.The regulation and activation of lupus-associated B cells.Regulation of antibody production mediated by Fc gamma receptors, IgG binding factors, and IgG Fc-binding autoantibodies.The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.Autoreactive B cells in the marginal zone that express dual receptorsA novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus.Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.
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The role of clonal selection and somatic mutation in autoimmunity
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в серпні 1987
@uk
name
The role of clonal selection and somatic mutation in autoimmunity
@en
The role of clonal selection and somatic mutation in autoimmunity
@nl
type
label
The role of clonal selection and somatic mutation in autoimmunity
@en
The role of clonal selection and somatic mutation in autoimmunity
@nl
prefLabel
The role of clonal selection and somatic mutation in autoimmunity
@en
The role of clonal selection and somatic mutation in autoimmunity
@nl
P2093
P356
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P1476
The role of clonal selection and somatic mutation in autoimmunity
@en
P2093
Marshak-Rothstein A
Rothstein TL
Shlomchik MJ
Weigert MG
Wolfowicz CB
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P304
P356
10.1038/328805A0
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P577
1987-08-01T00:00:00Z
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1048879260