about
Oxidative stress, bone marrow failure, and genome instability in hematopoietic stem cellsContinued primer synthesis at stalled replication forks contributes to checkpoint activation.Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling.APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress.Study of the DNA damage checkpoint using Xenopus egg extracts.APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.Cell-free Xenopus egg extracts for studying DNA damage response pathways.Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts.REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts.WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling.SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.APE2 promotes DNA damage response pathway from a single-strand break.Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2Managing a pending IBC approval. Communicate with the PIGenomic alterations and abnormal expression of APE2 in multiple cancersDistinct roles of XRCC1 in genome integrity in Xenopus egg extractsAPE1 senses DNA single-strand breaks for repair and signalingMethods for Studying DNA Single-Strand Break Repair and Signaling in Xenopus laevis Egg ExtractsOn the reproducibility of methods or findingsResolution of a complex crisis at DNA 3' termini
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P50
description
researcher ORCID ID = 0000-0001-8106-6295
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wetenschapper
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name
Shan Yan
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Shan Yan
@en
Shan Yan
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Shan Yan
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type
label
Shan Yan
@ast
Shan Yan
@en
Shan Yan
@es
Shan Yan
@nl
prefLabel
Shan Yan
@ast
Shan Yan
@en
Shan Yan
@es
Shan Yan
@nl
P31
P496
0000-0001-8106-6295