TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.
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A vertebrate gene, ticrr, is an essential checkpoint and replication regulatorThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationRescuing stalled or damaged replication forksStructure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Replication fork instability and the consequences of fork collisions from rereplicationThe N Terminus of the Retinoblastoma Protein Inhibits DNA Replication via a Bipartite Mechanism Disrupted in Partially Penetrant Retinoblastomas.Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATMRNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegansSUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathwayATR activation and replication fork restart are defective in FANCM-deficient cells.BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forksContinued primer synthesis at stalled replication forks contributes to checkpoint activation.ATRIP from TopBP1 to ATR--in vitro activation of a DNA damage checkpoint.Rad18-mediated translesion synthesis of bulky DNA adducts is coupled to activation of the Fanconi anemia DNA repair pathway.Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.The fork and the kinase: a DNA replication tale from a CHK1 perspective.TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.Transcriptome response to heat stress in a chicken hepatocellular carcinoma cell line.APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress.ATR signalling: more than meeting at the fork.APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.DNA damage tolerance: a double-edged sword guarding the genomeAkt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization.Cell-free Xenopus egg extracts for studying DNA damage response pathways.Clamping down on mammalian meiosis.Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.Functional genomic screens identify CINP as a genome maintenance protein.TopBP1 controls BLM protein level to maintain genome stabilityATR: a master conductor of cellular responses to DNA replication stress.The accumulation of DNA repair defects is the molecular origin of carcinogenesis.Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts.The essential kinase ATR: ensuring faithful duplication of a challenging genome.TopBP1-mediated DNA processing during mitosis.Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
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TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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TopBP1 and DNA polymerase-alph ...... stalled DNA replication forks.
@en
TopBP1 and DNA polymerase-alph ...... stalled DNA replication forks.
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TopBP1 and DNA polymerase-alph ...... stalled DNA replication forks.
@en
TopBP1 and DNA polymerase-alph ...... stalled DNA replication forks.
@nl
prefLabel
TopBP1 and DNA polymerase-alph ...... stalled DNA replication forks.
@en
TopBP1 and DNA polymerase-alph ...... stalled DNA replication forks.
@nl
P2860
P356
P1476
TopBP1 and DNA polymerase-alph ...... stalled DNA replication forks
@en
P2093
W Matthew Michael
P2860
P304
P356
10.1083/JCB.200810185
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P50
P577
2009-03-16T00:00:00Z