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Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammationJunB Inhibits ER Stress and Apoptosis in Pancreatic Beta CellsSTAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammationSelective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosisp53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stressCell-permeable peptides induce dose- and length-dependent cytotoxic effects.Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cellsA20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosisInitiation and execution of lipotoxic ER stress in pancreatic beta-cells.Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach.Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro.Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells.Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII.Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling.Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.Prolactin protects against cytokine-induced beta cell death by NFkB and JNK inhibition.The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes.40th EASD Annual Meeting of the European Association for the Study of DiabetesPancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammationImmunopurification of polyclonal antibodies to recombinant proteins of the same gene familyUse of pEX and pGEX bacterial heterologous protein expression systems for recombinant oncoprotein production and antisera generationInduction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cellsCytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activationSignaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis
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0000-0002-9551-2839