GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
about
The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionGolgi defects enhance APP amyloidogenic processing in Alzheimer's diseaseMultiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neuronsDepletion of GGA1 and GGA3 mediates postinjury elevation of BACE1A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagyApplication of Gaussia luciferase in bicistronic and non-conventional secretion reporter constructsThe Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models.The Alzheimer's disease beta-secretase enzyme, BACE1.The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP).Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptorsIntracellular trafficking of the β-secretase and processing of amyloid precursor protein.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondAutophagy modulation for Alzheimer's disease therapy.The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.Cholesterol-dependent energy transfer between fluorescent proteins-insights into protein proximity of APP and BACE1 in different membranes in Niemann-Pick type C disease cells.
P2860
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P2860
GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
GGA1 acts as a spatial switch ...... in trafficking and processing.
@en
type
label
GGA1 acts as a spatial switch ...... in trafficking and processing.
@en
prefLabel
GGA1 acts as a spatial switch ...... in trafficking and processing.
@en
P2093
P1476
GGA1 acts as a spatial switch ...... ein trafficking and processing
@en
P2093
Bradley T Hyman
Christine A F von Arnim
Hisatomo Kowa
Meihua Deng
Michael C Irizarry
Mirjam Koker
Robert Spoelgen
Stephanie Courchesne
Toshifumi Matsui
P304
P356
10.1523/JNEUROSCI.2290-06.2006
P407
P577
2006-09-01T00:00:00Z