about
Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expressionCrystal structure of the superantigen staphylococcal enterotoxin type AThe Co-crystal structure of staphylococcal enterotoxin type A with Zn2+ at 2.7 A resolution. Implications for major histocompatibility complex class II bindingSelective induction of p38 mitogen-activated protein kinase activity following A6H co-stimulation in primary human CD4(+) T cells.Antibody-targeted superantigens are potent inducers of tumor-infiltrating T lymphocytes in vivoA mutation of F47 to A in staphylococcus enterotoxin A activates the T-cell receptor Vbeta repertoire in vivoMonoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy.Tumor therapy with an antibody-targeted superantigen generates a dichotomy between local and systemic immune responses.Genetically engineered superantigens as tolerable antitumor agents.Staphylococcal enterotoxin-dependent cell-mediated cytotoxicity.The distinct role of CD4+ and CD8+ T-cells during the anti-tumour effects of targeted superantigens.Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen.Staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity.Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.Superantigen activation of CD4+ and CD8+T cells from HIV-infected subjects: role of costimulatory molecules and antigen-presenting cells (APC)Costimulation by B7-1 and LFA-3 targets distinct nuclear factors that bind to the interleukin-2 promoter: B7-1 negatively regulates LFA-3-induced NF-AT DNA binding.Expression of CD11a and CD45R isoforms defines distinct subsets of CD8+ TCR alpha beta and TCR gamma delta CTL in vivo.Targeting of superantigens.Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer.Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A.Monoclonal antibodies and superantigens: a novel therapeutic approach.Staphylococcal enterotoxin H displays unique MHC class II-binding properties.Rapid tyrosine phosphorylation of Lck following ligation of the tumor-associated cell surface molecule A6H.Staphylococcal enterotoxin-A directly stimulates signal transduction and interferon-gamma production in psoriatic T-cell lines.ICAM-1 costimulation induces IL-2 but inhibits IL-10 production in superantigen-activated human CD4+ T cells.Antibody-directed superantigen-mediated T-cell killing of myeloid leukaemic cell line cells.Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors.The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization.Gene transfer of a hybrid interleukin-1 beta gene to B16 mouse melanoma recruits leucocyte subsets and reduces tumour growth in vivo.Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.A superantigen-antibody fusion protein for T-cell immunotherapy of human B-lineage malignancies.The tumour associated cell surface antigen A6H is costimulatory for human CD4+ but not CD8+ T cells.T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles.Allogeneic heart transplantation activates alloreactive NK cells.Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release.Genetically engineered superantigens in experimental tumor therapy.A novel co-stimulatory T cell antigen co-expressed on renal cell carcinoma.Costimulation of human CD4+ T lymphocytes with B7 and lymphocyte function-associated antigen-3 results in distinct cell activation profiles.Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody.
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description
Swedish researcher
@en
Zweeds onderzoeker
@nl
svensk forsker
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name
Mikael Dohlsten
@da
Mikael Dohlsten
@de
Mikael Dohlsten
@en
Mikael Dohlsten
@es
Mikael Dohlsten
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Mikael Dohlsten
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Mikael Dohlsten
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Mikael Dohlsten
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Mikael Dohlsten
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Mikael Dohlsten
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type
label
Mikael Dohlsten
@da
Mikael Dohlsten
@de
Mikael Dohlsten
@en
Mikael Dohlsten
@es
Mikael Dohlsten
@fr
Mikael Dohlsten
@nb
Mikael Dohlsten
@nl
Mikael Dohlsten
@nn
Mikael Dohlsten
@sl
Mikael Dohlsten
@sv
prefLabel
Mikael Dohlsten
@da
Mikael Dohlsten
@de
Mikael Dohlsten
@en
Mikael Dohlsten
@es
Mikael Dohlsten
@fr
Mikael Dohlsten
@nb
Mikael Dohlsten
@nl
Mikael Dohlsten
@nn
Mikael Dohlsten
@sl
Mikael Dohlsten
@sv